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. 2017 Feb 12;64(9):1283–1288. doi: 10.1093/cid/cix129

Table 4.

Examples of Experimental Virologic and Host Markers and Endpoints

Assay Specimen Measures Reference
Virologic markers
Hepatitis B core– related antigen (q) Blood Denatured HBeAg, HBcAg, precore protein p22cr [14, 17]
cccDNA (q) Liver Number of infected hepatocytes [20]
Integrated DNA (q) Blood Infected cell number [2]
HBV RNA Blood cccDNA amount of transcription [22]
Host markers
PD1, Tim3, CTLA4 expression (q) on HBV-specific CD8 T cells by flow cytometry PBMC Exhaustion status of virus-specific T cells [34]
CD127 on HBV- specific T cells by flow cytometry/ functional assays Blood Long-lived HBV-specific memory T cells [27, 34]
Cytokines (q) Blood Inflammation [27, 35]
HBsAg epitopes PBMC HBsAg clearance [25]

Abbreviations: cccDNA, covalently closed circular DNA; HBcAg, hepatitis B core antigen; HBeAg, hepatitis B e antigen; HBsAg, hepatitis B surface antigen; HBV, hepatitis B virus; PBMC, peripheral blood mononuclear cells; q, quantitative result; non-q, nonquantitative result.