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. 2017 Jul 6;65(5):819–826. doi: 10.1093/cid/cix357

Figure 2.

Figure 2.

Effect of treatment completion on cytokine/chemokine expression following active TB (n = 15). A, Effect of treatment following the first TB episode, during early ART. Expression of 2 analytes was decreased IP10 (mean difference (MD) 0.271, 95% CI 0.0618 to 0.4803, P = .0148), sCD14 (MD = 0.0847, 95% CI 0.0186–0.1508, P = .0157), whereas IL6 (MD = 0.222, 95% CI −0.0461 to 0.4909, P = .097) and IFNγ (MD = 0.4687, 95% CI −0.2097 to 1.1472. P = .159) expression was not significantly affected. B, Effect of treatment following the recurrent TB episode. Expression of 4 analytes was decreased following TB treatment completion, including IP10 (MD = 0.281, 95% CI −0.0167 to 0.5788 P = .0625), sCD14 (MD = 0.1289, 95% CI 0.0249–0.2328, P = .0187), IL6 (MD = 0.5352, 95% CI 0.1913–0.8791, P = .0049), IFNγ (MD = 0.6821, 95% CI 0.1313–1.233, P = .0188). Paired t-test was used to evaluate changes in analyte expression between different time points. (Cytokines significantly affected at either of the time-points are shown here. Information for the rest of the measured cytokines can be found in Sup. Table 1). Abbreviations: ART, antiretroviral therapy; CI, confidence interval; IL, interleukin; IFN, interferon; IP, interferon gamma induced protein; sCD, soluble CD; TB, tuberculosis.