Table 1.
Clinical and Demographic Cohort Characteristics
| Variable | TB recurrence (N = 65) | No TB recurrence (N = 130) | P-Value |
|---|---|---|---|
| SAPiT enrollment | |||
| Randomization arm, n (%) | |||
| Early integrated arm | 17 (26.1) | 34 (26.1) | |
| Late integrated arm | 25 (38.5) | 50 (38.5) | |
| Sequential arm | 23 (35.4) | 46 (35.4) | |
| Age (y), median (IQR) | 32 (29–38) | 35 (28–41) | .719 |
| Body mass index (kg/m2), median (IQR) | 22.35 (20.2–24.7) | 22 (19.7–24.7) | .235 |
| CD4 count (cells/mm3), median (IQR) | 145 (57–234) | 151 (77–247) | .159 |
| Viral load (log copies/mL), mean (SD)a | 5.1 (0.8) | 5.0 (0.8) | .201 |
| Sex, n (%) | |||
| Male | 30 (46.2) | 60 (46.2) | - |
| Female | 35 (53.8) | 70 (53.8) | |
| WHO stage, n (%)b | |||
| 3 | 59 (93.7) | 116 (96.7) | .180 |
| 4 | 4 (6.3) | 4 (3.3) | |
| History of TB, n (%) | |||
| Yes | 28 (43.1) | 39 (30.0) | .024 |
| No | 37 (56.9) | 91 (70.0) | |
| Lung cavities, n (%)c | |||
| Both | 8 (13.3) | 11 (9.4) | .635 |
| No | 33 (55.0) | 70 (59.8) | |
| One | 19 (31.7) | 36 (30.8) | |
| SAPiT ART initiation | |||
| CD4 count (cells/mm3), median (IQR) | 119 (51–249) | 172 (88–264) | .159 |
| Viral load (log copies/ml), mean (SD)d | 5.0 (0.8) | 4.9 (0.9) | .272 |
| End of TB treatment in SAPiT | |||
| CD4 count (cells/mm3), median (IQR) | 212.5 (101.5–445.5) | 233.5 (127.5–353.5) | .634 |
| Viral load, n (%)e | |||
| Detectable | 22 (37.9) | 53 (44.9) | .096 |
| Undetectable | 36 (62.1) | 65 (55.1) | |
| Variables at sample collection | |||
| Age (y), median (IQR) | 34 (31–40) | 37 (31–43) | .789 |
| CD4 count (cells/mm3), median (IQR) | 344 (127–551) | 402 (257–547) | .011 |
| Viral load, n (%)f | |||
| Detectable | 26 (40.0) | 29 (22.5) | .03 |
| Undetectable | 39 (60.0) | 100 (77.5) | |
| History of IRIS, n (%) | |||
| IRIS | 12 (18.5) | 17 (13.1) | .281 |
| No IRIS | 53 (81.5) | 113 (86.9) | |
Missing data: a8, b12, c18, d2, e19, f1.
Abbreviations: ART, antiretroviral therapy; IQR, interquartile range; IRIS, immune reconstitution inflammatory syndrome; SD, standard deviation; TB, tuberculosis; WHO, World Health Organization.