Table 2.
Influence of Different Cytokines on Tuberculosis Recurrence
| Cytokine | Univariate | Multivariateb | ||
|---|---|---|---|---|
| OR (95% CI) | P-Value | OR (95% CI) | P-Value | |
| IL1β | 1.89 (0.97–3.68) | .064 | 3.41 (1.26–9.24) | .016 |
| IL1Rα | 1.52 (0.95–2.45) | .084 | 2.04 (1.04–3.98) | .038 |
| IL6 | 2.66 (1.34–5.27) | .005 | 4.79 (1.66–13.81) | .004 |
| IL7 | 1.27 (0.53–3.03) | .591 | 1.73 (0.48–6.31) | .403 |
| IL10 | 1.08 (0.58–2.01) | .814 | 1.61 (0.63–4.12) | .317 |
| IP10 | 4.62 (1.69–12.65) | .003 | 3.74 (0.90–15.53) | .069 |
| TNFα | 0.98 (0.57–1.67) | .934 | 1.04 (0.48–2.27) | .916 |
| IL1α | 0.95 (0.33–2.69) | .916 | 1.26 (0.32–4.97) | .739 |
| MIG | 3.11 (1.10–8.82) | .034 | 2.92 (0.81–10.57) | .103 |
| IFNβ | 0.34 (0.13–0.87) | .025 | 0.27 (0.07–0.99) | .049 |
| IFNα2 | 0.99 (0.48–2.02) | .967 | 0.59 (0.19–1.84) | .369 |
| IFNγ | 0.83 (0.57–1.22) | .349 | 0.69 (0.42–1.16) | .167 |
| IL18 | 1.38 (0.80–2.38) | .249 | 1.53 (0.75–3.11) | .241 |
| IL12P40 | 1.83 (0.66–5.09) | .244 | 3.44 (0.79–15.02) | .101 |
| sCD14 | 0.90 (0.08–10.42) | .931 | 0.83 (0.04–17.41) | .902 |
| IL15a | 0.20 (0.02–1.64) | .133 | 0.39 (0.03–4.69) | .460 |
| IFNλ1a | 0.80 (0.26–2.51) | .706 | 0.56 (0.14–2.29) | .419 |
| IL2a | 0.73 (0.29–1.84) | .500 | 0.64 (0.16–2.52) | .519 |
| IL27a | 0.64 (0.28–1.46) | .288 | 0.72 (0.22–2.31) | .580 |
| IL8a | 1.10 (0.53–2.28) | .803 | 1.14 (0.45–2.88) | .780 |
| IFNλ2a | 1.49 (0.72–3.11) | .284 | 1.69 (0.60–4.72) | .319 |
| IL12P7a | 1.15 (0.56–2.35) | .713 | 1.72 (0.62–4.78) | .298 |
| I-FABa | 1.27 (0.66–2.44) | .476 | 1.00 (0.44–2.27) | .993 |
Abbreviations: CI, confidence interval; IFN, interferon; IL, interleukin; IP, interferon gamma induced protein; MIG, monokine induced by IFN-γ; OR, odds ratio; sCD, soluble CD; TNF, tumor necrosis factor.
aAnalyzed as binary variables.
bMultivariate analyses adjusted for WHO stage of the disease, body mass index, lung cavities, age, CD4+ count, viral load, previous history of TB, history of IRIS. Viral load closer to sample collection was predictive of TB recurrence in all multivariate models.