Table 1.
Relation Between In Situ Hybridization Signals and Block Age in Xenograft Tissues by Image Analysisa
| Characteristic | Block Age, y | |||
|---|---|---|---|---|
| 0 | 1 | 2 | 5 | |
| PPIB | ||||
| Quartile | ||||
| 1 (lowest) | 2 (3.4) | 4 (7.6) | 12 (22.6) | 39 (65.0) |
| 2 | 12 (20.3) | 12 (22.6) | 22 (41.5) | 10 (16.7) |
| 3 | 18 (30.5) | 19 (35.9) | 14 (26.4) | 6 (10.0) |
| 4 (highest) | 27 (45.8) | 18 (34.0) | 5 (9.4) | 5 (8.3) |
| P < .0001, χ2 | ||||
| MYC | ||||
| Quartile | ||||
| 1 (lowest) | 7 (11.7) | 5 (9.4) | 9 (17.0) | 36 (60.0) |
| 2 | 11 (18.3) | 14 (26.4) | 24 (45.3) | 7 (11.7) |
| 3 | 17 (28.3) | 19 (35.9) | 9 (17.0) | 12 (20.0) |
| 4 (highest) | 25 (41.7) | 15 (28.3) | 11 (21.0) | 5 (8.3) |
| P < .0001, χ2 | ||||
| AR | ||||
| Quartile | ||||
| 1 (lowest) | 3 (5.1) | 7 (13.2) | 6 (11.3) | 41 (69.5) |
| 2 | 11 (18.6) | 14 (26.4) | 25 (47.2) | 6 (10.2) |
| 3 | 20 (33.9) | 18 (34.0) | 10 (18.9) | 8 (13.6) |
| 4 (highest) | 25 (42.3) | 14 (26.4) | 12 (22.6) | 4 (6.8) |
| P < .0001, χ2 | ||||
| 5.8S | ||||
| Quartile | ||||
| 1 (lowest) | 9 (15.3) | 5 (9.4) | 19 (35.9) | 23 (39.7) |
| 2 | 14 (23.7) | 16 (30.2) | 17 (32.1) | 9 (15.5) |
| 3 | 17 (28.8) | 20 (37.7) | 11 (20.8) | 8 (13.8) |
| 4 (highest) | 19 (32.2) | 12 (22.6) | 6 (11.3) | 18 (31.0) |
| P < .0292, χ2 | ||||
aValues are presented as number (column percentages) in each quartile across all three patient-derived xenographs examined.