Table 2.
Total and Direct Effect of Selected Characteristics on Risk of H30 Infection Versus Infection With Other Escherichia coli Types Using Log-Binomial Regression Models Stratified by Extended-Spectrum Cephalosporin Resistance Status
| Characteristic | ESC-R | ESC-S | ||||
|---|---|---|---|---|---|---|
| Total Effect RR (95% CI) | Direct Effect RR (95% CI) | Total Effect RR (95% CI) | Direct Effect RR (95% CI) | |||
| Crude | Adjusteda | Adjusteda | Crude | Adjusteda | Adjusteda | |
| Age 0–5 y | 1.98 (1.30–3.01)* | 1.83 (1.19–2.83)*,b | 1.91 (1.24–2.96)*,c | 0.48 (.27–.87)* | … | 0.52 (.29–.94)*,d |
| Antibiotics in last 30 d | … | … | … | 2.18 (1.22–3.91)* | 1.18 (.64–2.20)e | … |
| Underlying medical condition | … | … | … | 4.46 (2.42–8.21)* | 4.49 (2.43–8.31)*,f | 3.53 (1.74–7.17)*,g |
| Hospitalization in past 6 mo | … | … | … | 2.08 (1.12–3.84)* | 1.22 (.65–2.30)h | 1.01 (.51–2.00)i |
| Presence of indwelling device | … | … | … | 3.33 (1.87–5.92)* | 1.54 (.78–3.04)j | 1.53 (.77–3.01)d |
Abbreviations: CI, confidence interval; ESC-R, extended-spectrum cephalosporin-resistant; ESC-S, extended-spectrum cephalosporin-susceptible; RR, relative risk.
aAll models adjusted for study hospital.
bAdditional covariates: Asian race (yes/no).
cAdditional covariates: Asian race (yes/no), underlying medical condition (yes/no), antibiotics in the last 30 days (yes/no), hospitalization in the past 6 months (yes/no).
dAdditional covariates: underlying medical condition (yes/no), antibiotics in the last 30 days (yes/no), hospitalization in the past 6 months (yes/no).
eAdditional covariates: age (0–5 or 6–21), hospitalization in the past 6 months (yes/no), underlying medical condition (yes/no), indwelling device (yes/no).
fAdditional covariates: age (0–5 or 6–21).
gAdditional covariates: age (0–5 or 6–21), hospitalization in the past 6 months (yes/no), antibiotics in the last 30 days (yes/no), indwelling device (yes/no).
hAdditional covariates: age (0–5 or 6–21), underlying medical condition (yes/no).
iAdditional covariates: age (0–5 or 6–21), underlying medical condition (yes/no), antibiotics in the last 30 days, indwelling device (yes/no).
jAdditional covariates: underlying medical condition (yes/no), hospitalization in the past 6 months (yes/no).
*Confidence interval does not include 1.