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NLRP1 inflammasome signalling in the eye. Activation of toll like-receptor 4 in turn recruits caspase-8 which can induce the secretion of IL-1β directly; alternatively caspase-8 can activate the NLRP1 inflammasome which recruits caspase-1 to cleave pro IL-1β into its active form which is then transported out of the cell.
