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Activation mechanism of inflammasomes. Assembly of inflammasomes in response to activation signals and post activation effects. (a) Activation signal. (b) Recruitment of ASC by NLR. (c) Inflammasome assembly. (d) Interaction of CARD-CARD domains lead to autoproteolysis. (e) Cleavage of procaspase-1 into caspase-1. (f) Processing of proIL-1β to biologically active IL-1β by caspase-1. (g) Release of IL-1β results in inflammation of tissue. (h) Release of IL-1β results in pyroptosis.
