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. 2017 Aug 21;66(2):220–228. doi: 10.1093/cid/cix753

Figure 2.

Figure 2.

Serum vitamin D (25-OHD) concentration and change in lumbar spine (L1–L4) bone mineral density (BMD) by study week and vitamin D randomized dose group. Data are median and bars are Q1, Q3. P values shown in the figures are for the change from baseline to each study week. A, For both the vitamin D3 and placebo group, 25-OHD values at weeks 12, 24, and 48 were significantly higher than baseline. *25-OH-D change from baseline differed between dose groups (P < .001). †25-OHD at weeks 12, 24, and 48 differed between dose groups (P < .001). Vitamin D3, n = 100; placebo, n = 91. B, At week 48, the change from baseline was significant in the vitamin D3 group but not in the placebo group. There was no significant difference in the change from baseline to week 48 between the vitamin D3 and placebo groups (P = .117). C, Vitamin D3, n = 99; placebo, n = 89; 25-OHD <20 ng/mL, n = 59; 25-OHD >20 ng/mL, n = 40.