Table 1.
Invasive pneumococcal disease incidence after PCV10/13 vaccination compared to before PCV7 and PCV10/13 vaccination according to serotype and age group in the whole of Sweden
| Age group (years) | Serotype | Pre-PCV7 Incidenceb (2007) | Pre-PCV10/13 Incidenceb (2007–2009) | Post-PCV10/13 Incidenceb (2013–2016) | Post-PCV10/13 vs. Pre-PCV7 Rate Ratio (95% CI)c | Post-PCV10/13 vs. Pre-PCV10/13 Rate Ratio (95% CI)c |
|---|---|---|---|---|---|---|
| 0–4 | (N = 73) | (N = 210) | (N = 120) | |||
| All serotypes | 13.9 (11.0,17.5) | 13.0 (11.4,14.9) | 5.1 (4.3,6.1) | 0.37 (0.28,0.49) | 0.39 (0.31,0.49) | |
| 4,6B,9V,14, 18C,19F,23F | 9.4 (7.0,12.5) | 7.9 (6.5,9.6) | 0.4 (0.2,0.9) | 0.05 (0.02,0.1) | 0.06 (0.03,0.11) | |
| 1,5,7F | 1.4 (0.6,2.8) | 1.6 (1.0,2.3) | 0.1 (0.02,0.4) | 0.07 (0.01,0.35) | 0.06 (0.01,0.27) | |
| 1 | 0 (0.0,0.7)a | 0.1 (0.03,0.5) | 0 (0,0.2)a | - | 0 (0,2.4)a | |
| 7F | 1.4 (0.6,2.8) | 1.4 (0.9,2.2) | 0.1 (0.02,0.4) | 0.07 (0.01,0.35) | 0.07 (0.01,0.3) | |
| 3,6A,19A | 2.1 (1.1,4.1) | 2.1 (1.4,3.1) | 1.3 (0.9,1.9) | 0.62 (0.3,1.28) | 0.62 (0.37,1.08) | |
| 3 | 0.2 (0.03,1.8) | 0.6 (0.3,1.2) | 0.7 (0.4,1.1) | 2.85 (0.36,22.8) | 1.2 (0.47,3.1) | |
| 6A | 1.2 (0.5,2.6) | 0.7 (0.4,1.2) | 0.1 (0.02,0.34) | 0.07 (0.01,0.36) | 0.13 (0.03,0.59) | |
| 19A | 0.7 (0.2,2.3) | 0.9 (0.5,1.7) | 0.6 (0.3,1.0) | 0.81 (0.22,3.0) | 0.64 (0.28,1.49) | |
| NVT | 1.0 (0.3,3.1) | 1.4 (0.8,2.5) | 3.2 (2.6,4.1) | 3.41 (1.02,11.4) | 2.27 (1.26,4.1) | |
| 5–64 | (N = 648) | N = (2097) | (N = 1794) | |||
| All serotypes | 9.2 (8.5,9.9) | 9.9 (9.5,10.3) | 6.1 (5.9,6.4) | 0.67 (0.61,0.73) | 0.62 (0.58,0.66) | |
| 4,6B,9V,14, 18C,19F,23F | 4.7 (4.2,5.3) | 4.7 (4.4,5.1) | 0.5 (0.4,0.6) | 0.1 (0.08,0.13) | 0.1 (0.09,0.13) | |
| 1,5,7F | 1.4 (1.1,1.8) | 1.9 (1.7,2.1) | 0.5 (0.5,0.6) | 0.38 (0.29,0.51) | 0.29 (0.24,0.35) | |
| 1 | 0.2 (0.1,0.4) | 0.4 (0.3,0.5) | 0.1 (0.06,0.1) | 0.39 (0.20,0.73) | 0.26 (0.16,0.40) | |
| 7F | 1.2 (0.9,1.5) | 1.5 (1.3,1.7) | 0.4 (0.4,0.5) | 0.37 (0.27,0.51) | 0.29 (0.23,0.36) | |
| 3,6A,19A | 1.3 (1.0,1.6) | 1.3 (1.1,1.5) | 1.5 (1.3,1.6) | 1.18 (0.91,1.52) | 1.14 (0.97,1.35) | |
| 3 | 0.8 (0.5,1.0) | 0.8 (0.6,0.9) | 0.9 (0.8,1.0) | 1.22 (0.88,1.73) | 1.23 (0.99,1.54) | |
| 6A | 0.3 (0.2,0.5) | 0.3 (0.2,0.4) | 0.03 (0.02,0.07) | 0.1 (0.04,0.24) | 0.12 (0.05,0.27) | |
| 19A | 0.1 (0.06,0.3) | 0.3 (0.2,0.3) | 0.5 (0.4,0.6) | 3.52 (1.51,8.21) | 2.03 (1.42,2.91) | |
| NVT | 1.8 (1.4,2.2) | 2.0 (1.7,2.2) | 3.6 (3.4,3.9) | 2.0 (1.65,2.52) | 1.85 (1.62,2.11) | |
| ≥65 | (N = 738) | (N = 2545) | (N = 3168) | |||
| All serotypes | 45.9 (42.7,49.3) | 51.5 (49.5,53.5) | 41.1 (39.7,42.6) | 0.9 (0.83,0.97) | 0.8 (0.76,0.84) | |
| 4,6B,9V,14, 18C,19F,23F | 24.3 (21.8,27.1) | 25.4 (23.7,27.1) | 2.8 (2.5,3.3) | 0.12 (0.1,0.14) | 0.11 (0.1,0.13) | |
| 1,5,7F | 3.3 (2.4,4.6) | 3.5 (2.9,4.2) | 1.3 (1.1,1.7) | 0.4 (0.27,0.6) | 0.38 (0.29,0.51) | |
| 1 | 0.2 (0.06,0.6) | 0.3 (0.2,0.6) | 0.1 (0.04,0.2) | 0.53 (0.13,2.13) | 0.3 (0.11,0.86) | |
| 7F | 3.0 (2.1,4.2) | 3.1 (2.6,3.8) | 1.2 (1.0,1.5) | 0.41 (0.28,0.61) | 0.39 (0.29,0.53) | |
| 3,6A,19A | 8.4 (7.0,10.2) | 9.7 (8.8,10.7) | 9.8 (9.1,10.6) | 1.16 (0.95,1.42) | 1.01 (0.89,1.14) | |
| 3 | 4.6 (3.5,5.9) | 4.8 (4.1,5.5) | 6.2 (5.6,6.8) | 1.36 (1.04,1.77) | 1.3 (1.09,1.55) | |
| 6A | 2.7 (2.0,3.7) | 3.1 (2.6,3.7) | 0.5 (0.4,0.7) | 0.2 (0.12,0.31) | 0.17 (0.12,0.25) | |
| 19A | 1.2 (0.6,2.2) | 1.8 (1.4,2.4) | 3.1 (2.7,3.5) | 2.67 (1.38,5.15) | 1.68 (1.26,2.24) | |
| NVT | 9.8 (8.2,11.8) | 12.8 (11.7,14.1) | 27.1 (25.9,28.2) | 2.76 (2.28,3.34) | 2.11 (1.9,2.34) | |
| All age groups | (N = 1459) | (N = 4852) | (N = 5082) | |||
| All serotypes | 15.9 (15.1,16.7) | 17.5 (17.0,18.0) | 13.0 (12.6,13.3) | 0.82 (0.77,0.86) | 0.74 (0.71,0.77) | |
| 4, 6B, 9V, 14, 18C,19F, 23F | 8.4 (7.8,9.1) | 8.6 (8.2,9.0) | 1.0 (0.9,1.1) | 0.11 (0.1,0.13) | 0.11 (0.1,0.12) | |
| 1,5,7F | 1.7 (1.5,2.0) | 2.2 (2.0,2.3) | 0.7 (0.6,0.8) | 0.39 (0.31,0.47) | 0.31 (0.27,0.37) | |
| 1 | 0.2 (0.1,0.4) | 0.3 (0.3,0.4) | 0.09 (0.06,0.13) | 0.41 (0.23,0.72) | 0.26 (0.17,0.39) | |
| 7F | 1.5 (1.3,1.8) | 1.8 (1.6,2.0) | 0.6 (0.5,0.7) | 0.38 (0.3,0.48) | 0.32 (0.27,0.38) | |
| 3,6A,19A | 2.6 (2.2,2.9) | 2.8 (2.6,3.1) | 3.1 (2.9,3.3) | 1.21 (1.04,1.41) | 1.09 (0.99,1.2) | |
| 3 | 1.4 (1.1,1.7) | 1.5 (1.3,1.6) | 1.9 (1.8,2.1) | 1.4 (1.13,1.72) | 1.34 (1.17,1.54) | |
| 6A | 0.8 (0.6,1.0) | 0.8 (0.7,0.9) | 0.13 (0.1,0.19) | 0.17 (0.11,0.25) | 0.17 (0.12,0.24) | |
| 19A | 0.4 (0.2,0.6) | 0.6 (0.5,0.7) | 1.0 (0.9,1.1) | 2.87 (1.69,4.85) | 1.79 (1.43,2.24) | |
| NVT | 3.1 (2.7,3.6) | 3.9 (3.6,4.2) | 8.2 (7.9,8.5) | 2.61 (2.26,3.02) | 2.12 (1.96,2.3) |
aThese calculations were made by using an exact method on the observed data.
bIncidence per 100000 population in year (95% Confidence Interval)
cSignificant changes in rate ratios in bold