Table 3.

Allele and genotype frequencies of S100B SNPs in the validation cohort

	Controls		Early onset PD		Late onset PD		p-Valuea	p-Valueb	OR
	n	Frequency	n	Frequency	n	Frequency
rs9722
C	679	0.913	37	0.841	325	0.950	0.005	0.109	3.6 (1.4–9.3)
T	65	0.087	7	0.159	17	0.050
CC	312	0.839	16	0.727	157	0.918	0.021	0.277
TC	55	0.148	5	0.227	11	0.064
TT	5	0.013	1	0.045	3	0.018
rs2239574
C	515	0.689	27	0.643	238	0.704	0.415	0.535	1.3 (0.7–2.6)
T	233	0.311	15	0.357	100	0.296
CC	172	0.460	9	0.429	86	0.509	0.731	0.635
TC	171	0.457	9	0.429	66	0.391
TT	31	0.083	3	0.143	17	0.101
rs881827
C	537	0.718	38	0.864	240	0.702	0.024	0.035	2.7 (1.1–6.6)
T	211	0.282	6	0.136	102	0.298
CC	200	0.535	17	0.773	85	0.497	0.051	0.093
TC	137	0.366	4	0.182	70	0.409
TT	37	0.099	1	0.045	16	0.094
rs9984765
T	549	0.736	31	0.705	260	0.760	0.420	0.647	1.3 (0.7–2.7)
C	197	0.264	13	0.295	82	0.240
TT	202	0.539	11	0.500	104	0.608	0.587	0.883
CT	148	0.395	9	0.409	52	0.304
CC	25	0.067	2	0.091	15	0.088
rs1051169
C	475	0.656	26	0.591	224	0.663	0.346	0.378	1.4 (0.7–2.6)
G	249	0.344	18	0.409	114	0.337
CC	156	0.430	9	0.409	77	0.456	0.469	0.284
GC	165	0.455	8	0.364	70	0.414
GG	42	0.116	5	0.227	22	0.130

Significant (p < 0.05) results are shown in bold. ^aEarly onset PD (≤50 years) compared to late onset PD (> 50 years). ^bEarly onset PD compared to controls. ^cOR (95% confidence interval) for early onset PD compared to controls. P-values were calculated from Chis-square test and ORs were calculated using logistic regression