Table 1.
Mucosal pro- and active MMP-2 and -9 activities in dogs with CE and healthy dogs
| Intestinal part | Group | Activity | |||
|---|---|---|---|---|---|
| Pro MMP-2 (AU) median (range) | Active MMP-2 (AU) median (range) | Pro MMP-9 (AU) median (range) | Active MMP-9 (AU) median (range) | ||
| Duodenum | Dogs with CE (n = 35) | 0.01 (0–1.66) | 0 (0–0.02) | 0.06 (0–3.86) | 0 (0–0.21) |
| Healthy dogs (n = 18) | 0 (0–0.64) | 0 (0–0) | 0.03 (0–3.32) | 0 (0–0) | |
| Ileum | Dogs with CE (n = 12) | 0.02 (0–0.83) | 0 (0–0.01) | 0.06 (0–0.5) | 0 (0–0.28) |
| Healthy dogs (n = 18) | 0 (0–0.52) | 0 (0–0) | 0.03 (0–0.45) | 0 (0–0) | |
| Colon | Dogs with CE (n = 15) | 0.03 (0–0.55) | 0 (0–0.05) | 0.07 (0.02–0.92) | 0 (0–0.04) |
| Healthy dogs (n = 18) | 0 (0–0.64) | 0 (0–0) | 0 (0–0.79) | 0 (0–0) | |
| Cecum | Dogs with CE (n = 6) | 0.0 (0.01–1.48) | 0 (0–0.01) | 0.09 (0.02–0.59) | 0.005 (0–0.05) |
| Healthy dogs (n = 6) | 0 (0–0.3) | 0 (0–0) | 0.18 (0–0.82) | 0 (0–0) | |
Pro- and active MMP-2 and -9 activities were measured in the mucosal samples from duodenum, ileum, colon, and cecum of dogs with CE and healthy dogs
AU arbitrary units; CE chronic enteropathies; Pro pro-enzyme