Table 1.

In vivo reprogramming methodologies. Neural in vivo reprogramming methodologies used to generate neurons or neural progenitors from diverse cell types. Cells of origin annotated with a superscript H denote human cells transplanted into rodent neural tissue for in vivo reprogramming.

Cell of origin	Reprogramming factor(s)	Induced fate (reference)
Glial cell
Astrocyte	ASCL1, POU3F2, and MYT1L	Neuron (Torper et al., 2013)
AstrocyteH	ASCL1, POU3F2, and MYT1L	Neuron (Torper et al., 2013)
Cortical astrocyte	NEUROD1	Glutamatergic neuron (Guo et al., 2014)
Cortical NG2 glial cell	NEUROD1	Glutamatergic neuron (Guo et al., 2014)
Cortical NG2 glial cell	NEUROD1	GABAergic neuron (Guo et al., 2014)
Cortical NG2 glial cell	SOX2 ± ASCL1	Neuron (Heinrich et al., 2014)
Cortical glial cell	NEUROG2 ± FGF2 + EGF	Glutamatergic neuron (Grande et al., 2013)
Spinal astrocyte	SOX2	Neuroblast (Su et al., 2014)
Spinal astrocyte	SOX2, valproic acid	Neuron (Su et al., 2014)
Striatal astrocyte	SOX2	Neuroblast (Niu et al., 2013)
Striatal astrocyte	SOX2, valproic acid	Neuron (Niu et al., 2013)
Striatal glial cell	NEUROG2 ± FGF2 + EGF	GABAergic neuron (Grande et al., 2013)
Progenitor
Neural progenitor	FEZF2	Cortical projection neuron (Rouaux and Arlotta, 2010)
Neuron
Callosal projection neuron	FEZF2	Corticofugal projection neuron (Rouaux and Arlotta, 2013)
Spiny neuron	FEZF2	Pyramidal neuron (De la Rossa et al., 2013)
Somatic
FibroblastH	ASCL1, POU3F2, and MYT1L	Neuron (Torper et al., 2013)
FibroblastH	ASCL1, POU3F2, MYT1L, OTX2, LMX1A, LMX1B, and FOXA2	Dopaminergic neuron (Torper et al., 2013)

Defined abbreviation: EGF + FGF2, epidermal growth factor and fibroblast growth factor 2.