Table 3.
Side effects of different treatment regiments
| RBAL | RBMT | RAL | p value* | |||
|---|---|---|---|---|---|---|
| Side effects of treatment (yes), % | 54.1a | 52.3a | 26.2b | >0.05 | <0.001 | <0.001 |
| Patients withdrawn due to side effects | 5 (4.5) | 9 (8.1) | 6 (5.6) | >0.05 | >0.05 | >0.05 |
| Side effects | ||||||
| Nausea | 37 (33.3)a | 45 (40.5)a | 13 (12.1)b | >0.05 | <0.001 | <0.001 |
| Vomiting | 6 (5.4)a | 11 (9.9)a | 0 (0.0)b | >0.05 | <0.001 | 0.015 |
| Metallic taste | 0 (0.0)a | 23 (20.7)b | 0 (0.0)a | <0.001 | <0.001 | >0.05 |
| Itchiness | 8 (7.2) | 6 (5.4) | 5 (4.7) | >0.05 | >0.05 | >0.05 |
| Skin rash | 5 (4.5) | 4 (3.6) | 7 (6.5) | >0.05 | >0.05 | >0.05 |
| Constipation | 0 (0.0) | 1 (0.9) | 0 (0.0) | >0.05 | >0.05 | >0.05 |
| Diarrhea | 14 (12.6)a | 4 (3.6)b | 13 (12.1)a | 0.014 | 0.019 | >0.05 |
| Dysphagia | 1 (0.9)a | 21 (18.9)b | 0 (0.0)a | <0.001 | >0.001 | >0.05 |
| Chest pain | 1 (0.9)a | 9 (8.1)b | 0 (0.0)a | 0.010 | 0.003 | >0.05 |
| Darkened stool | 47 (42.3)a | 51 (45.9)a | 0 (0.0)b | >0.05 | <0.001 | <0.001 |
| Black tongue | 12 (10.8)a | 27 (24.3)b | 0 (0.0)c | 0.08 | >0.001 | <0.001 |
| Vaginal discharge | 5 (4.5) | 1 (0.9) | 5 (4.7) | >0.05 | >0.05 | >0.05 |
| Headache | 7 (6.3) | 1 (0.9) | 4 (3.7) | >0.05 | >0.05 | >0.05 |
| Abdominal pain | 13 (11.7) | 11 (9.9) | 9 (8.4) | >0.05 | >0.05 | >0.05 |
Data are presented as n (%) unless otherwise indicated. See Table 1 footnote for abbreviations.
*
Three p values were used for 3 comparisons: RBAL vs. RBMT, RBMT vs. RAL, and RBAL vs. RAL, respectively.
a
Protocols within a row without a common superscript differ.
b
Protocols within a row without a common superscript differ.
c
Protocols within a row without a common superscript differ.