TABLE 4.
Reproducibility of clinical sample results for our LC/MS/MS-based method to analyze ATV in small hair samples*
| Participant sample no | Normalized original conc. (ng/mg) | Normalized repeat conc. (ng/mg) | Average normalized conc. (ng/mg) | Difference (%)** |
|---|---|---|---|---|
| 1 | 2.75 | 2.99 | 2.87 | 8.36 |
| 2 | 6.09 | 5.49 | 5.79 | −10.4 |
| 3 | 2.25 | 2.85 | 2.55 | 23.5 |
| 4 | 3.20 | 3.40 | 3.30 | 6.06 |
| 5 | 17.3 | 15.7 | 16.5 | −9.70 |
| 6 | 1.92 | 1.61 | 1.77 | −17.5 |
| 7 | 2.97 | 2.80 | 2.89 | −5.88 |
| 8 | 1.27 | 1.50 | 1.39 | 16.5 |
| 9 | 1.87 | 2.28 | 2.08 | 19.7 |
| 10 | NA | NA | NA | ND |
| 11 | 3.30 | 3.62 | 3.46 | 9.25 |
| 12 | 3.07 | 3.60 | 3.34 | 15.9 |
| 13 | 2.46 | 3.06 | 2.76 | 21.7 |
| 14 | 2.09 | 2.11 | 2.10 | 0.952 |
| 15 | 3.72 | 3.84 | 3.78 | 3.17 |
| 16 | 2.39 | 2.61 | 2.50 | 8.80 |
| 17 | 2.20 | 2.18 | 2.19 | −0.913 |
| 18 | 3.25 | 3.45 | 3.35 | 5.97 |
| 19 | 2.20 | 2.37 | 2.29 | 7.42 |
| 20 | 5.15 | 5.59 | 5.37 | 8.19 |
*
FDA incorporated Incurred Sample Reanalysis Table.
**
Percentage (%) Difference = ((Normalized repeat conc. − Normalized original conc.)/(Average normalized conc.) × 100.
NA – Not Applicable; ND – No Difference