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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Gastroenterology. 2017 Sep 25;154(1):168–180.e5. doi: 10.1053/j.gastro.2017.09.019

Figure 7. Chylomicron metabolism is Cu dependent.

Figure 7

(A) Enteroids derived from both WT and Atp7b-/- duodenum recapitulate the chylomicron phenotype observed in parent tissues. Cu treatment and Cu chelation of WT enteroids reduces the chylomicron load in enterocytes compared to basal levels demonstrating that the process is Cu dependent. White arrows point out chylomicrons stained green with Bodipy. (B) Proposed model for ATP7B-dependent Cu storage in enterocytes and its role in chylomicron assembly.