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. 2018 Mar 12;9:12. doi: 10.1186/s13293-018-0171-0

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Octave band noise exposure at 101 dB SPL causes PTS in 10-week-old B6CBAF1/J mice. Hearing thresholds were compared between baseline, 24 h, 8 days, and 15 days post-noise exposure. At 24 h post-noise, significant compound threshold shifts are seen across all frequencies tested. Significant permanent threshold shifts are also detected at all frequencies tested at 8 and 15 days post-noise exposure. (**p < 0.01; **** p < 0.0001; ns non-significant)