Table 4.
Characteristics of follicular and mature nodal peripheral T-cell lymphomas in outpatient and inpatient cohorts
| Follicular lymphoma (N = 562) | Nodal peripheral T-cell lymphoma (N = 261) | |||||
|---|---|---|---|---|---|---|
| Characteristic | OPs 1 (n = 439) | IP 2 (n = 123) | P value 1 vs 2 | OPs 1 (n = 160) | IP 2 (n = 101) | P value 1 vs 2 |
| Age (years), mean (SD) | 61.1 (18.4) | 65.6 (13.6) | <.001 | 62.1 (14.3) | 68.5 (12.4) | <.001 |
| ≤ 60, n (%) | 212 (48.3) | 40 (32.5) | <.001 | 75 (46.9) | 21 (20.8) | <.001 |
| > 60, n (%) | 227 (51.7) | 83 (67.5) | <.001 | 85 (53.1) | 80 (79.2) | <.001 |
| Sex, n (%) | ||||||
| Females | 224 (51.0) | 59 (48.0) | .071 | 67 (41.9) | 38 (37.6) | .066 |
| Males | 215 (49.0) | 64 (52.0) | .074 | 93 (58.1) | 63 (62.4) | .068 |
| Clinical manifestations, n (%) | ||||||
| Lymphadenopathy | 356 (81.1) | 82 (66.7) | <.001 | 91 (56.9) | 39 (38.6) | <.001 |
| Systemic symptoms | 52 (11.8) | 19 (15.4) | .058 | 54 (33.8) | 47 (46.5) | <.001 |
| Pain symptoms | 13 (3.0) | 9 (7.3) | .037 | 10 (6.3) | 13 (12.9) | <.001 |
| Chest symptoms | 12 (2.7) | 8 (6.5) | .054 | 3 (1.9) | 1 (1.0) | .211 |
| Other symptoms/signs | 6 (1.4) | 5 (4.1) | .086 | 2 (1.3) | 1 (1.0) | .235 |
| Successive/first visit ratio | 2.10 | 2.66 | ||||
| QDU time for diagnosis /admission time for diagnosis (days), mean (SD) | 15.8 (1.8) | 11.5 (2.3) | .002 | 18.3 (2.4) | 14.9 (3.0) | .007 |
| Suspected/compatible lymphoma by FNAC, n (%)/total n | 230 (68.5)/336 | 33 (70.2)/47 | .143 | 45 (58.4)/77 | 19 (57.6)/33 | .215 |
| Time to FNAC (days), mean (SD) | 1.4 (0.7) | 1.3 (0.5) | .120 | 1.1 (0.6) | 1.2 (0.4) | .184 |
| Time to excisional biopsy (days), mean (SD) | 7.6 (1.5) | 3.8 (1.0) | .006 | 7.2 (1.3) | 2.9 (0.8) | <.001 |
| ECOG performance score > 1, n (%)/total n | 24 (5.7)/418 | 12 (10.4)/115 | .031 | 48 (31.6)/152 | 37 (37.8)/98 | .020 |
| B symptoms, n (%) | 61 (13.9) | 24 (19.5) | .020 | 90 (56.3) | 64 (63.4) | <.001 |
| Serum LDH > UNL, n (%) | 92 (21.0) | 34 (27.6) | .003 | 96 (60.0) | 69 (68.3) | <.001 |
| Extranodal disease, n (%) | 38 (8.7) | 14 (11.4) | .093 | |||
| > 1 extranodal site, n (%) | 63 (39.4) | 52 (51.5) | <.001 | |||
| Histologic grading, n (%) | ||||||
| 1 | 123 (28.0) | 33 (26.8) | .157 | |||
| 2 | 172 (39.2) | 48 (39.0) | .208 | |||
| 3A | 114 (26.0) | 36 (29.3) | .063 | |||
| Unspecified | 30 (6.8) | 6 (4.9) | .135 | |||
| Ann Arbor stage, n (%) | ||||||
| I-II | 156 (35.5) | 38 (30.9) | .033 | 36 (22.5) | 14 (13.9) | <.001 |
| III-IV | 283 (64.5) | 85 (69.1) | .034 | 124 (77.5) | 87 (86.1) | <.001 |
| FLIPI score, n (%)/total n | ||||||
| Low risk (0-1) | 165 (37.6)/439 | 41 (33.3)/123 | .040 | |||
| Intermediate risk (2) | 153 (34.9)/439 | 43 (35.0)/123 | .214 | |||
| High risk (3-5) | 121 (27.6)/439 | 39 (31.7)/123 | .049 | |||
| IPI score, n (%)/total n | ||||||
| Low risk (0-1) | 30 (19.7)/152 | 13 (13.3)/98 | .008 | |||
| Intermediate risk (2-3) | 75 (49.3)/152 | 47 (48.0)/98 | .179 | |||
| High risk (4-5) | 47 (30.9)/152 | 38 (38.8)/98 | <.001 | |||
Abbreviations: FLIPI follicular lymphoma international prognostic index
For other abbreviations, definitions, and explanations, see Tables 1 and 3
Missing data: variables ‘time to FNAC’ (follicular lymphoma: OPs = 8, IPs = 5; nodal peripheral T-cell lymphoma: OPs = 4, IPs = 3), ‘time to excisional biopsy’ (follicular lymphoma: OPs = 2, IPs = 2; nodal peripheral T-cell lymphoma: OPs = 1, IPs = 0), ‘B symptoms’ (follicular lymphoma: OPs = 2, IPs = 0; nodal peripheral T-cell lymphoma: OPs = 3, IPs = 2)