FIG. 6.

Four-state Markov models fitted by Gin et al. (Ref. 38). Closed states are ${\text{C}}_1$, ${\text{C}}_2$, and ${\text{C}}_3$. Open state is ${\text{O}}_4$. Left: model 1, right: model 2. Rate constants given by $q_{ij}$ denoting the transition from state $i$ to state $j$.