Table 1.
Baseline characteristics and Risk factors for mortality in patients with ventilator- associated pneumonia.
| Total (n=167) | Survivors (n=125) | Non survivors (n=42) | p-Value | |
|---|---|---|---|---|
| Age (year), median (IQR) | 58 (29) | 56 (27) | 60.5(33) | 0.743 |
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| Gender (F/M) (n) | 55/112 | 40/85 | 15/27 | 0.800 |
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| Admission place for ICU (n) | 0.237 | |||
| – Community | 54 | 37 | 17 | |
| – Wards | 78 | 64 | 14 | |
| – Other ICU | 24 | 17 | 7 | |
| – Other Hospital | 11 | 7 | 4 | |
|
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| Reason of ICU admission (n) | 0.512 | |||
| – Pulmonary | 52 | 42 | 10 | |
| – Cardiac | 11 | 7 | 4 | |
| – Neurologic | 25 | 19 | 6 | |
| – Sepsis | 21 | 11 | 10 | |
| – Trauma | 27 | 24 | 3 | |
| – Intoxication | 5 | 4 | 1 | |
| – Other | 13 | 12 | 1 | |
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| Underlying disease (n) | ||||
| – Hypertension | 59 | 43 | 16 | 0.805 |
| – Diabetes mellitus | 27 | 16 | 11 | 0.072 |
| – Neurologic disease | 28 | 23 | 5 | 0.462 |
| – Malignancy | 24 | 18 | 6 | 1.00 |
| – COPD | 21 | 14 | 7 | 0.512 |
| – CAD | 17 | 10 | 7 | 0.139 |
| – CHF | 11 | 8 | 3 | 1.00 |
| – CRF | 16 | 10 | 6 | 0.236 |
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| APACHE II scoreAdmission | 23 (9) | 21 (8.5) | 24 (6.3) | 0.016* |
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| SOFAAdmission median (IQR) | 7 (3) | 6 (4) | 7.5 (2.3) | <0.001* |
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| SOFAat VAP diagnosis | 7 (3) | 6 (4) | 8(2.3) | <0.001* |
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| GCSAdmission | 6 (6) | 7 (7) | 5 (4) | 0.053 |
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| PaO2/FIO2Admission | 247.4±114.1 | 253.6±116.7 | 228.8±105.3 | 0.241 |
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| PaO2/FIO2 at VAP diagnosis | 140.69±45.2 | 148.40±44.9 | 117.73±37.9 | <0.001* |
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| Duration of MV (day), median (IQR) | 7 (4) | 7 (3) | 6.5 (5) | 0.029* |
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| PEEP (>5 cmH2O) | 154 | 113 | 41 | 0.188 |
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| VAP | 1.00 | |||
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| Early (n) | 40 | 30 | 10 | |
| Late (n) | 127 | 95 | 32 | |
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| Empirical antibiotic treatment(n) | 167 | 125 | 42 | 0.449 |
| Appropriate | 82 | 64 | 18 | |
| Inappropriate | 85 | 61 | 24 | |
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| Secondary bacteremia (n) | 17 | 10 | 7 | 0.138 |
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| Use of corticosteroid (n) | 22 | 15 | 7 | 0.610 |
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| Dialysis (n) | 16 | 10 | 6 | 0.236 |
MV – mechanical ventilation; DM – diabetes mellitus; COPD – chronic obstructive pulmonary disease; CAD – coronary artery disease; CHF – congestive heart failure; CRF – chronic renal failure; APACHE – acute physiology and chronic health evaluation; SOFA – sequential organ failure assesment; PEEP – positive end-expiratory pressure; GCS – Glasgow coma score;
*
p<0.05 accepted as statistically significant.
IQR – interquantile range.