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. 2018 Mar 13;5:180035. doi: 10.1038/sdata.2018.35

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Copyright © 2018, The Author(s)

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ The Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the metadata files made available in this article.

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Via k-means clustering genes were assigned to 100 clusters having similar behaviour during the hepatic differentiation process. The plots in (a) show expression of genes in the hESC-differentiation experiments associated with cluster#94 representative for hESCs, cluster#23 containing SOX17 representative for DE, cluster#64 representative for HE, cluster#77 representative for HLCs, cluster#19 containing AFP representative for fetal liver, cluster#59 containing the liver marker ALB representative for PHHs. The plots in (b) show expression of genes in the iPSC-differentiation experiments associated with cluster#68 representative for iPSCs, cluster#81 containing SOX17 representative for DE, cluster#37 representative for HE, cluster#51 representative for HLCs, cluster#72 containing AFP representative for fetal liver, cluster#91 containing the liver marker ALB representative for PHHs.