Table 4.

Time to CD4⁺ <500 cell/mm³ Drop Analysis of Validation Cohort

Factor	P; HR (95% CI)	P; HR (95% CI)
	Unadjusted	Adjusted
Sex (male)	.066; .585 (.330–1.036)
Age at human immunodeficiency virus diagnosis (years)	.091; 1.562 (.931–2.621)	.043; 1.770 (1.019–3.076)
Interferon-lambda 4 A/A genotype	.038; 1.717 (1.030–2.865)	.037; 1.790 (1.035–3.096)
HLA-B*27	.972; 1.041 (.540–1.894)
HLA-B*57	.029; .490 (.257–.935)	.045; .510 (.271–.985)
HLA-B*35	.425; .661 (.258–1.835)
HLA-B*08	.157; 1.725 (.811–3.662)

Significant values are shown in bold.

Abbreviations: HR, hazard ratio; CI, confidence interval; HLA, human leukocyte antigen.