Table 1.
Animal Models of Preeclampsia and Data Regarding Complement Involvement
| Model | Placental abnormalities | Hypertension | Proteinuria | Fetal growth restriction | Angiogenic imbalance | Endothelial dysfunction | References |
|---|---|---|---|---|---|---|---|
| Genetic Models (Stage 1 and 2) | |||||||
| BPH/5 mouse | + | + | + | + | + | + | 49, 50 |
| C1q def mouse | + | + | + | + | + | + | 52, 55 |
| CBA/JXDBA/2 mouse | + | − | + | + | + | ? | 60–62 |
| Dahl SS rat | + | + | + | + | + | ? | 64, 65 |
| Surgical or Pharmacological Induction (Stage 2) | |||||||
| RUPP rat | − | + | − | + | + | + | 87, 88, 89, 92 |
| AT1-AA infusion mouse | − | + | + | + | + | ? | 90 |
| Complement involvement | No data for complement involvement | Complement not involved | |||||
AT1-AA, agonistic IgG autoantibodies to angiotensin II Type 1 receptor
RUPP, reduced uteroplacental perfusion pressure model of placental ischemia-induced hypertension
+ Symptom occurs
? Not determined
− Symptom does not occur