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. Author manuscript; available in PMC: 2019 Mar 25.
Published in final edited form as: Eur J Med Chem. 2018 Feb 12;148:195–209. doi: 10.1016/j.ejmech.2018.02.031

Table 4.

Caco-2 bidirectional permeability analysis for compounds 9 and 19.

Test compound Assay Duration (minutes) Mean A→B Papp (10−6 cm/sec) Mean B→A Papp (10−6 cm/sec) Efflux ratio (Papp(B→A)/(Papp(A→B) P-gp substrate Notes
Colchicine 60 0.13 5.54 44.30
Ranitidine 60 0.27 1.71 6.30 Yes Poor-permeability control
Labetolol 60 8.81 35.05 Yes Moderate-permeability control
Propranolol 60 24.99 42.44 1.70 No High-permeability control
9 60 0.05 0.35 69 Yes Low permeability
19 60 0.13 0.13 0.96 No Low permeability