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Metabolic stability analysis for compounds 9 and 19 in HLM.
| Test Article | Test Concentration (μM) | Mean CLint (μL/min-mg) | Mean t1/2 (minutes) | Notes |
|---|---|---|---|---|
| Terfenadine | 0.1 | 774.0 | 8.95 | High clearance control |
| Verapamil | 0.1 | 286.6 | 24.20 | High clearance control |
| Propranolol | 0.1 | < 115.5 | 143.80 | Low clearance control |
| Imipramine | 0.1 | <115.5 | 87.20 | Low clearance control |
| 9 | 0.1 | < 115.5 | 292.00 | Stable to metabolism |
| 19 | 0.1 | <115.5 | 476.30 | Stable to metabolism |
