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. Author manuscript; available in PMC: 2018 Mar 13.
Published in final edited form as: JAMA Psychiatry. 2014 Apr;71(4):412–422. doi: 10.1001/jamapsychiatry.2013.4506

Table 1.

Characteristics of aMCI Patients, svMCI Patients, and Individuals With NC

Characteristic aMCI svMCI P
Valueb 		NC
(n = 75)		 P
Valuec
Total
(n = 45)		 PiB−
(n = 17)		 PiB+
(n = 28)		 P
Valuea 		Total
(n = 67)		 PiB−
(n = 45)		 PiB+
(n = 22)		 P
Valuea
Age, mean (SD), y 70.0 (8.0) 70.6 (7.8) 69.7 (8.3) .70 73.7 (6.7) 72.1 (6.6) 76.9 (5.9) .006 .01 63.6 (8.2) <.001
Female sex, No. (%) 20 (44) 9 (53) 11 (39) .37 41 (61) 29 (64) 12 (54) .44 .08 57 (76) .17
Educational level, mean (SD), y 12.5 (4.6) 11.4 (5.9) 13.1 (3.5) .29 9.4 (5.4) 9.0 (5.2) 10.2 (5.8) .38 .001 12.0 (4.8) .002
Vascular risk factors, No. (%)
  Hypertension 17 (38) 10 (59) 7 (25) .02 50 (75) 38 (84) 12 (54) .008 <.001 14 (19) <.001
  Diabetes mellitus 5 (11) 4 (24) 1 (4) .06 17 (25) 12 (27) 5 (23) .73 .06 31 (41) .11
  Hyperlipidemia 10 (22) 3 (18) 7 (25) .72 20 (30) 14 (31) 6 (27) .75 .37 18 (24) .40
  Cardiac disease 7 (16) 3 (18) 4 (14) >.99 17 (25) 12 (27) 5 (23) .73 .21 14 (19) .30
  Stroke 2 (4) 2 (12) 0 .14 13 (19) 9 (20) 4 (18) >.99 .02 3 (4) .009
APOE genotyping, No. (%)d
  APOE4 allele 17 (44) 0 17 (71) <.001 15 (22) 5 (11) 10 (46) .004 .02 NA
  APOE2 allele 3 (8) 3 (20) 0 .05 10 (15) 6 (13) 4 (18) .72 .27 NA
PiB retention ratio, mean (SD)
  Total 1.87 (0.51) 1.31 (0.12) 2.20 (0.33) 1.50 (0.40) 1.27 (0.10) 1.98 (0.35) <.001
  Frontal 1.84 (0.52) 1.27 (0.12) 2.19 (0.34) 1.48 (0.42) 1.23 (0.10) 1.98 (0.38) <.001
  Parietal 1.78 (0.53) 1.24 (0.17) 2.11 (0.40) 1.40 (0.42) 1.16 (0.12) 1.90 (0.38) <.001
  Temporal 1.86 (0.50) 1.33 (0.14) 2.18 (0.34) 1.49 (0.38) 1.27 (0.12) 1.93 (0.33) <.001
MRI markers of ischemia, mean (SD)
  Total WMH, mL 3.1 (3.2) 3.5 (3.1) 2.9 (3.2) .65 34.9 (17.8) 33.8 (17.6) 36.8 (18.4) .44 <.001 1.3 (1.6) <.001
    Frontal 20.0 (9.4) 19.7 (9.8) 20.6 (8.9) .74
    Parietal 8.9 (5.7) 8.7 (5.5) 9.3 (6.1) .68
    Temporal 3.5 (1.9) 3.3 (1.8) 3.8 (2.1) .30
  Total supratentorial lacunes, No. 0.5 (2.2) 1.3 (3.4) 0.1 (0.4) .07 7.2 (8.1) 8.0 (8.2) 5.5 (7.8) .40 <.001 0.5 (1.1) <.001
    Frontal 6.0 (6.6) 7.0 (7.3) 4.1 (4.4) .05
    Parietal 1.0 (3.3) 0.9 (2.1) 1.4 (4.9) .58
    Temporal 0.2 (0.9) 0.3 (1.1) 0 .10
  Total supratentorial MBs, No. 0.8 (3.5) 1.2 (4.6) 0.6 (2.7) .66 5.3 (11.2) 4.8 (9.5) 6.1 (14) .44 .01 0.7 (1.1) .003
    Frontal 2.7 (5.6) 3.3 (6.8) 2.4 (5.1) .58
    Parietal 0.5 (1.7) 0.3 (0.7) 1.0 (2.8) .29
    Temporal 1.2 (3.1) 1.0 (2.1) 1.7 (4.9) .50

Abbreviations: aMCI, amnestic mild cognitive impairment; APOE, apolipoprotein E; MBs, microbleeds; MRI, magnetic resonance imaging; NA, not applicable; NC, normal cognition; NCF, normal cognitive function; PiB, Pittsburgh Compound B; svMCI, subcortical vascular mild cognitive impairment; WMH, white matter hyperintensity; +, positive; −, negative.

a

Comparison of PiB+ vs PiB− participants.

b

Comparison of aMCI vs svMCI participants.

c

Comparison of NCF vs PiB− svMCI participants.

d

Six patients with aMCI (4 PiB+ and 2 PiB−) refused the APOE4 genotype testing.