Table 2.
Neuropsychological Testsa
| Mean (SD) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
|||||||||||
| aMCI | svMCI | ||||||||||
|
|
|
||||||||||
| Test (Possible Range of Score) |
Total (n = 45) |
PiB− (n = 17) |
PiB+ (n = 28) |
P Valueb |
Total (n = 67) |
PiB− (n = 45) |
PiB+ (n = 22) |
P Valueb |
P Valuec |
NC (n = 75) |
P Valued |
| Digit span | |||||||||||
|
| |||||||||||
| Forward (0–9) | 5.8 (1.4) | 5.5 (1.4) | 6.0 (1.5) | .71 | 5.2 (1.3) | 5.1 (1.3) | 5.5 (1.2) | .16 | .83 | 6.4 (1.4) | .07 |
|
| |||||||||||
| Backward (0–8) | 4.0 (1.4) | 3.4 (1.1) | 4.4 (1.5) | .08 | 3.2 (1.1) | 3.2 (1.1) | 3.3 (1.2) | .55 | .28 | 4.4 (1.4) | .04 |
|
| |||||||||||
| BNT (0–60) | 41.4 (9.6) | 38.2 (9.1) | 43.4 (9.5) | .19 | 39.1 (10.4) | 41.2 (9.2) | 34.9 (11.7) | .006 | .49 | 50.5 (5.7) | <.001 |
|
| |||||||||||
| RCFT (0–36) | 30.9 (4.5) | 31.4 (3.8) | 30.6 (5.6) | .30 | 27.5 (7.6) | 28.2 (6.9) | 26.1 (8.8) | .22 | .34 | 33.5 (2.1) | <.001 |
|
| |||||||||||
| SVLT | |||||||||||
|
| |||||||||||
| Immediate recall (0–36) | 15.0 (4.2) | 15.4 (4.0) | 14.8 (4.3) | .37 | 16.5 (5.4) | 16.9 (5.4) | 15.7 (5.3) | .91 | .09 | 22.5 (4.4) | <.001 |
|
| |||||||||||
| Delayed recall (0–12) | 2.4 (2.4) | 3.5 (2.0) | 1.7 (2.3) | .01 | 4.3 (2.9) | 4.8 (2.8) | 3.2 (2.9) | .25 | .001 | 7.6 (2.0) | <.001 |
|
| |||||||||||
| Recognition (0–24) | 18.5 (2.9) | 19.9 (2.2) | 17.7 (3.0) | .007 | 19.3 (2.9) | 19.9 (2.1) | 18.1 (3.8) | .11 | .43 | 21.6 (1.7) | .001 |
|
| |||||||||||
| RCFT | |||||||||||
|
| |||||||||||
| Immediate recall (0–36) | 8.4 (5.7) | 10.5 (4.5) | 7.2 (6.0) | .06 | 10.6 (6.2) | 11.4 (6.0) | 8.8 (6.5) | .06 | .03 | 18.4 (5.0) | <.001 |
|
| |||||||||||
| Delayed recall (0–36) | 7.0 (5.4) | 9.1 (4.2) | 5.8 (5.8) | .049 | 10.2 (5.8) | 11.4 (5.3) | 7.6 (6.0) | .008 | <.001 | 17.7 (4.8) | <.001 |
|
| |||||||||||
| Recognition (0–24) | 18.0 (2.1) | 19.3 (2.0) | 17.3 (1.9) | .001 | 19.2 (2.2) | 19.6 (1.9) | 18.4 (2.4) | .05 | .001 | 20.2 (1.5) | .45 |
|
| |||||||||||
| COWAT | |||||||||||
|
| |||||||||||
| Animal | 13.4 (4.3) | 11.9 (3.4) | 14.4 (4.6) | .09 | 11.7 (3.6) | 12.2 (3.5) | 10.6 (3.8) | .10 | .17 | 17.3 (4.9) | <.001 |
|
| |||||||||||
| Supermarket | 13.2 (5.4) | 12.8 (4.2) | 13.5 (6.0) | .83 | 13.1 (4.9) | 13.3 (5.2) | 12.5 (4.2) | .42 | .39 | 18.6 (5.6) | <.001 |
|
| |||||||||||
| Phonemic | 23.6 (11.6) | 19.6 (7.5) | 26.0 (13.1) | .15 | 16.4 (8.9) | 15.9 (9.1) | 17.5 (8.5) | .63 | .07 | 28.7 (11.6) | <.001 |
|
| |||||||||||
| Stroop test: color (0–112) | 67.7 (24.3) | 63.3 (21.9) | 70.4 (25.6) | .64 | 59.4 (26.5) | 64.3 (24.7) | 49.5 (27.8) | .048 | .85 | 93.5 (18.3) | <.001 |
|
| |||||||||||
| MMSE (0–30) | 25.5 (4.6) | 26.9 (2.0) | 24.6 (5.6) | .07 | 26.2 (3.0) | 26.6 (2.4) | 25.4 (3.9) | .17 | .04 | 28.8 (1.5) | <.001 |
|
| |||||||||||
| CDR-SOB (0–30) | 1.7 (1.1) | 1.4 (0.9) | 1.9 (1.1) | .14 | 1.4 (1.1) | 1.3 (1.0) | 1.5 (1.1) | .58 | .09 | 0.5 (0.4) | <.001 |
Abbreviations: aMCI, amnestic mild cognitive impairment; BNT, Boston Naming Test; CDR-SOB, Clinical Dementia Rating Scale Sum of Boxes; COWAT, Controlled Oral Word Association Test; MMSE, Mini-Mental State Examination; NC, normal cognition; PiB, Pittsburgh Compound B; RCFT, Rey-Osterrieth Complex Figure Test; SVLT, Seoul Verbal Learning Test; svMCI, subcortical vascular mild cognitive impairment; +, positive; −, negative.
a
P values were adjusted for age and years of education.
b
Comparison of PiB+ vs PiB− participants.
c
Comparison of aMCI vs svMCI participants.
d
Comparison of NC vs PiB− svMCI participants.