Table 4.
Evaluations at Assessment Closest to Abscess
| Variable | No. | (%) | No. | (%) | P Value | ||
|---|---|---|---|---|---|---|---|
| Binary variables | |||||||
| Sex (female = 1) | 19 | (51.3) | 248 | (60.1) | .26 | ||
| Cerebral abscess | 37 | (100) | 0 | (0) | |||
| Clinical ischemic stroke | 3 | (8.1) | 55 | (13.4) | .41 | ||
| Migraine | 11 | (29.7) | 112 | (27.5) | .51 | ||
| Multiple PAVMs | 28 | (75.7) | 213 | (52.2) | .016 | ||
| Definite HHT | 34 | (91.9) | 368 | (90.2) | .62 | ||
| Use of oral iron | 10 | (27) | 109 | (26.7) | .63 | ||
| Use of intravenous iron | 4 | (10.8) | 14 | (3.4) | .018 | ||
| Use of blood transfusions | 4 | (10.8) | 23 | (5.6) | .16 | ||
| Cerebral hemorrhage | 0 | (0) | 3 | (0.73) | .6 | ||
| Liver transplantation for hepatic AVM | 0 | (0) | 1 | (0.25) | .76 | ||
| Smoking history | 8 | (21.6) | 92 | (22.5) | .98 | ||
| High blood pressure | 5 | (13.5) | 39 | (9.56) | .39 | ||
| Venous thromboemboli | 4 | (10.8) | 14 | (3.43) | .022 | ||
| Diabetes mellitus | 1 | (2.7) | 9 | (2.2) | .86 | ||
| Continuous variables | No. | Median (Q1, Q3) | Range | No. | Median (Q1, Q3) | Range | |
| Age, y | 37 | 50 (36, 62) | 19–76 | 408 | 48 (34, 62) | 16–89 | .6 |
| Oxygen saturation at abscess, % | 34 | 92.1 (89, 95) | 74–98 | 398 | 95.0 (91.8, 96.3) | 72–99 | .0016 |
| Hemoglobin, g/L | 35 | 144 (127, 158) | 74–203 | 391 | 140 (125, 155) | 59–201 | .39 |
| Arterial oxygen content, mL/dL | 34 | 17.9 (13.8, 19.2) | 9.4–21.3 | 385 | 17.5 (15.9, 19.2) | 7.6–24.3 | .75 |
| Platelet count, ×109/dL | 34 | 252 (208, 295) | 138–502 | 371 | 261 (221, 307) | 70–606 | .38 |
| Platelet volume, fL | 32 | 10.9 (10.3, 11.4) | 9.5–13 | 367 | 10.6 (10, 11.2) | 4.3–13.8 | .04 |
| Prothrombin time, sec | 32 | 11.0 (10.6, 11.4) | 9.9–22.8 | 367 | 10.7 (10.4, 11.2) | 9–38.1 | .037 |
| Activated partial thromboplastin time, sec | 32 | 26.3 (25.5, 28.3) | 19.3–36.5 | 365 | 26.2 (24.7, 28.1) | 13.2–43 | .53 |
| Fibrinogen, g/L | 32 | 3.1 (2.47, 3.59) | 1.47–4.65 | 361 | 3.03 (2.56, 3.58) | 1.55–7.16 | .8 |
| C-reactive protein, IU/mL | 30 | 2 (1.4, 4) | 0.2,21 | 354 | 2.0 (1.2, 3.8) | 0–118.2 | .66 |
| Serum iron, umol/L | 33 | 15 (8, 22) | 2.0–277.0 | 366 | 14 (8, 19) | 0–64 | .25 |
| Transferrin saturation index, % | 33 | 27 (13, 36) | 0–100 | 365 | 21 (11, 29) | 0–89 | .18 |
| Ferritin, μg/L | 31 | 34 (20, 83) | 3–151 | 342 | 34 (15, 73) | 0–1795 | .55 |
| Largest PAVM feeding artery diameter, mm | 25 | 5 (4, 6) | 1–10 | 307 | 5 (2, 6) | 0–14 | .58 |
| Pulmonary artery pressure, mean, mm Hg | 25 | 13 (12, 16) | 5–28 | 213 | 14 (12, 16) | 6–50 | .51 |
Range of interval to abscess: 9 months preabscess to 480 months postabscess (median, 9 months [interquartile range, 4–9 months] postabscess). Use of presentation data did not materially affect the respective ranks or P values (Supplementary Table 2).
Abbreviations: AVM, arteriovenous malformation; HHT, hereditary hemorrhagic telangiectasia; PAVM, pulmonary arteriovenous malformation.