Table 3.

Associations Between Sepsis Hospitalization and Risk of Subsequent Acute Coronary Heart Disease Events

	Sepsis Cases	Nonsepsis Controls	Risk of Acute CHD, Hazard Ratio (95% Confidence Interval)
	Acute CHD Events /No. at Risk (%)	Acute CHD Events /No. at Risk (%)	Crude	Model 1	Model 2	Model 3	Model 4
Traditional Cox proportional hazards model
	87/1070 (8.13)	209/5350 (3.91)	2.85 (2.17–3.75)	2.74 (2.07–3.64)	2.64 (1.99–3.52)	2.14 (1.53–3.01)	2.08 (1.55–2.79)
Piecewise Cox proportional hazards model
0–1 year	29/1070 (2.71)	45/5350 (0.84)	3.62 (2.24–5.86)	3.67 (2.16–6.26)	3.55 (2.07–6.11)	4.38 (2.03–9.45)	2.67 (1.58–4.49)
1–4 years	43/779 (5.52)	90/4630 (1.94)	3.22 (2.19–4.73)	2.94 (1.97–4.39)	2.86 (1.91–4.29)	1.78 (1.09–2.88)	2.05 (1.34–3.12)
4+ years	15/329 (4.56)	74 / 2,210 (3.35)	1.59 (0.86–2.94)	1.59 (0.84–3.01)	1.57 (0.82–3.02)	1.18 (0.52–2.67)	1.34 (0.70–2.56)

Model 1: adjusted for sex, race, education, income, and region. Model 2: additional adjustment for tobacco use. Model 3: additional adjustment for atrial fibrillation, chronic lung disease, diabetes, hypertension, obesity, peripheral artery disease, stroke, chronic kidney disease, and albumin-to-creatinine ratio. Model 4: adjusted only for REasons for Geographic And Racial Differences in Stroke sepsis risk score.

Abbreviation: CHD, coronary heart disease.