Table 3.
Adjusted Estimates of Relative Risk for Low Birth Weight, Small-for-Gestational Age, Preterm Birth, and Birth Weight z Score Outcomes by Maternal Perinatally Human Immunodeficiency Virus (HIV)-Infected Status and Maternal Age Among HIV-exposed Uninfected Infants Born to 13–30 year-old Women with HIV in the SMARTT or IMPAACT P1025 Studies
| Maternal Age Group | N | Low Birth Weight (<2500 g) | Small for Gestational Age | Preterm Birth | BWZ | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| % | RR (95% CI) | P | % | RR (95% CI) | P | % | RR (95% CI) | P | Difference (95% CI) | P | ||
| 13–17 y | ||||||||||||
| PHIV | 20 | 10% | 0.44 (0.10,1.89)a | .27 | 15% | 1.07 (0.29, 4.03)a | .92 | 10% | 0.67 (0.14, 3.16)a | .62 | -0.06 (-0.47, -0.35)a | .77 |
| NPHIV | 36 | 22% | 1.00 | 14% | 1.00 | 15% | 1.00 | |||||
| 18–22 y | ||||||||||||
| PHIV | 171 | 16% | 0.84 (0.53,1.34) | .47 | 12% | 0.94 (0.59, 1.51) | .79 | 14% | 0.77 (0.48, 1.24) | .29 | -0.08 (-0.24, 0.08) | .33 |
| NPHIV | 602 | 15% | 1.00 | 14% | 1.00 | 15% | 1.00 | |||||
| 23–30 y | ||||||||||||
| PHIV | 78 | 24% | 1.74 (1.18, 2.58) | <.01 | 12% | 1.24 (0.66, 2.34) | .51 | 19% | 1.30 (0.84, 2.02) | .24 | -0.13 (-0.33, 0.07) | .22 |
| NPHIV | 1692 | 15% | 1.00 | 10% | 1.00 | 17% | 1.00 | |||||
Abbreviations: BWZ, birth weight z score; CI, confidence interval; HIV, human immunodeficiency virus; NPHIV, nonperinatally HIV-infected; PHIV, perinatally HIV-infected; RR, relative risk.
aThe 13- to 17-year age group results are from unadjusted models due to small sample size. For age groups 18–22 and 23–30, models adjusted for race, earliest CD4 count in pregnancy, maternal substance use in pregnancy, maternal tobacco use during pregnancy, maternal prepregnancy body mass index, and most potent antiretroviral regimen in pregnancy.