Figure 5.

MGN1703 treatment activates memory subsets of CD4⁺ and CD8⁺ T cells. Flow cytometry analyses of fresh peripheral blood mononuclear cells were performed at the indicated time-points: baseline, day 0; late, day 24 (24 hours after eighth/last dose). A, HLA-DR⁺ and CD38⁺ coexpression analyses on CD4⁺ T-cell subsets: naive (T_N), central memory (T_CM), effector memory (T_EM), and terminal differentiated (T_TD). B, Proportions of the 4 CD4⁺ T-cell subsets of total CD4⁺ T cells. C, HLA-DR⁺ and CD38⁺ coexpression analyses on CD8⁺ T-cell subsets: T_N, T_CM, T_EM, T_TD. D, Proportions of the 4 CD8⁺ T-cell subsets of total CD8⁺ T cells (n = 11). Statistical comparisons were 2-tailed, Wilcoxon signed-rank test as paired analysis against baseline. *P < .05; **P < .01; ***P < .001.