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. 2018 Feb 14;9(16):13048–13059. doi: 10.18632/oncotarget.24495

Figure 4. miR-20a/CXCL8 levels of co-inoculated stromal fibroblasts influence tumor latency.

Figure 4

(A, B) Confirmation of miR-20a and CXCL8 in the ‘miR High’ and ‘miR Low’ colitis-associated fibroblasts used for the in vivo tumorigenicity experiments. (C–F) Co-injection of colon cancer stem cells (CA2) with and without the miR High and miR Low colitis-associated fibroblasts significantly altered disease progression (C) and tumor volume (D–F) at 5 and 6 weeks, but not 7 weeks after inoculation. (G, H) Images and quantification of the tumors stained for BrdU incorporation upon resection. All xenografts were harvested, when the longest dimension was 5–7 mm. Statistics were preformed using ANOVA and significance levels are indicated in the individual panels. Each group contained n ≥ 9 animals.