Table 2. Meta-analysis of the association between VDR polymorphisms and CRC.
| SNP | Comparison | Qualified studies | OR (95%CI) | P-value | FDR | Heterogeneity test | Effect model |
|---|---|---|---|---|---|---|---|
| FokI | F vs. f | 29 | 1.029 (0.999–1.059) | 0.057 | 0.057 | P = 0.003, I2 = 46.8% | F |
| FF vs. ff | 1.055 (0.990–1.123) | 0.097 | 0.211 | P = 0.015, I2 = 39.8% | F | ||
| FF + Ff vs. ff | 1.045 (0.986–1.107) | 0.141 | 0.211 | P = 0.124, I2 = 23.9% | F | ||
| Ff + ff vs. FF | 0.974 (0.876–1.083) | 0.625 | 0.625 | P < 0.001, I2 = 81.5% | R | ||
| BsmI | B vs. b | 23 | 0.862 (0.761–0.976) | 0.019* | 0.019* | P < 0.001, I2 = 91.4% | R |
| BB vs.bb | 0.786 (0.636–0.972) | 0.026* | 0.039* | P < 0.001, I2 = 85.5% | R | ||
| BB + Bb vs. bb | 0.824 (0.705–0.964) | 0.015* | 0.039* | P < 0.001, I2 = 88.0% | R | ||
| Bb + bb vs. BB | 0.887 (0.759–1.036) | 0.129 | 0.129 | P < 0.001, I2 = 78.8% | R | ||
| ApaI | A vs. a | 12 | 1.025 (0.928–1.132) | 0.631 | 0.631 | P < 0.001, I2 = 68.9% | R |
| AA vs. aa | 0.953 (0.775–1.172) | 0.650 | 0.900 | P < 0.001, I2 = 67.9% | R | ||
| AA + Aa vs. aa | 1.009 (0.875–1.163) | 0.900 | 0.900 | P = 0.003, I2 = 59.8% | R | ||
| Aa + aa vs. AA | 0.901 (0.770–1.055) | 0.197 | 0.591 | P = 0.001, I2 = 65.5% | R | ||
| TaqI | T vs. t | 18 | 1.011 (0.960–1.066) | 0.673 | 0.673 | P = 0.081, I2 = 33.1% | F |
| TT vs. tt | 1.027 (0.912–1.157) | 0.656 | 0.746 | P = 0.091, I2 = 32.5% | F | ||
| TT +Tt vs. tt | 1.018 (0.913–1.136) | 0.746 | 0.746 | P = 0.069, I2 = 35.4% | F | ||
| Tt + tt vs. TT | 1.013 (0.944–1.086) | 0.724 | 0.746 | P = 0.310, I2 = 11.8% | F | ||
| Cdx2 | C vs. c | 4 | 0.936 (0.828–1.058) | 0.287 | 0.287 | P = 0.352, I2 = 8.2% | F |
| CC vs. cc | 0.862 (0.627–1.186) | 0.363 | 0.544 | P = 0.193, I2 = 36.6% | F | ||
| CC + Cc vs. cc | 0.933 (0.723–1.204) | 0.594 | 0.594 | P = 0.176, I2 = 39.3% | F | ||
| Cc + cc vs. CC | 0.918 (0.783–1.077) | 0.293 | 0.544 | P = 0.777, I2 = 0.0% | F |
VDR, vitamin D receptor; CRC, Colorectal cancer; OR, odds ratios; 95% CI, 95% confidence interval; FDR: p value from Benjamini–Hochberg method control for false discovery rate (FDR); R, random-effects model; F, fixed-effects model; *statistical significance.