Table 3.

Predictive power for ADNI-WGS samples for three kinds of phenotype definitions and two covariate adjustments: (i) normal (=1), MCI (=2) and AD (=3) (measured by predictive correlation coefficient (SD)), (ii) normal (=1), MCI (=2) and AD (=2) (measured by AUC (SD)), (iii) normal (=1), MCI (=1) and AD (=2) (measured by AUC (SD)); (a) sex and age, (b) sex, age, year of education (EDU) and family history (FH). OptP, optimal p-value cutoff by STMGP (−log10 scale). NS, number of screened SNVs by STMGP.

(i)
Covariates	STMGP	GCTA	GS	OptP	NS
(a)	0.22 (0.11)	0.06 (0.14)	0.07 (0.11)	4.7 (0.5)	362 (350)
(b)	0.24 (0.12)	−0.06 (0.1)	0.05 (0.1)	4.9 (0.3)	247 (160)

(ii)
Covariates	STMGP	GCTA	GS	OptP	NS
(a)	0.61 (0.05)	0.54 (0.09)	0.51 (0.09)	4.8 (0.4)	143 (104)
(b)	0.63 (0.08)	0.44 (0.08)	0.51 (0.09)	4.8 (0.4)	113 (82)

(iii)
Covariates	STMGP	GCTA	GS	OptP	NS
(a)	0.60 (0.15)	0.51 (0.17)	0.52 (0.18)	3.5 (0)	3523 (309)
(b)	0.69 (0.15)	0.47 (0.15)	0.55 (0.21)	3.5 (0)	3601 (296)