FIG. 3.

Specificity of major P450 enzymes involved in eicosanoid production. Labels in red indicate that the enzyme only catalyzes the production of HETEs regioisomers. Labels in blue indicate that the enzyme catalyzes the production of both EETs and HETEs regioisomers. Labels in green indicate that the enzyme only catalyzes the production of EETs regioisomers. For clarity, cytochrome P450 enzyme names are preceded by the first letter of the species that they are found in, where h = human, m = mouse, r = rat, f = fish, R = rabbit, and s = sheep.