FIG. 4.

Potential modes of activation of HETEs and EETs receptors. Vascular reactivity is used as an example to depict potential ligand-receptor interactions and the subsequent effects on vascular reactivity that are dictated by the activation of different intracellular signaling pathways. (A) Mode A, in which HETEs and EETs bind to separate receptors to increase intracellular Ca²⁺ or cAMP, respectively. (B) Mode B, in which an EET acts as an antagonist for HETE. (C) Mode C, in which HETEs and EETs bind to the same receptor but at different sites to increase intracellular Ca²⁺ or cAMP, respectively. Gray downward triangle represents HETEs. Black square represents EETs. Black arrows indicate an increase or activation, whereas gray arrows indicate a decrease or inhibition in the downstream targets.