Table 1.

Summary of Potential Hydroxyeicosatetraenoic Acids and Epoxyeicosatrienoic Acids Receptors

Regioisomer	Receptor ID	Affinity	Ref.
12-HETE	GPR31	High	79
12(S)-HETE	PPARγ	Low	167
15-HETE	?	High	142,185
15-HETE	TP	Low	19,176
15(S)-HETE	PPARγ	Low	167
19-HETE	PTGIR	Low	179
20-HETE	TP	Low	13,19,56
11,12-EET	?	High	107
14,15-EET	?	High	37,38,192,198
14,15-EET	PPARγ	Low	114
14,15-EET	Prostaglandin receptors	Low	113,197

High affinity refers to effective concentrations <1 μM. Low affinity refers to effective concentrations ≤1 μM.

? indicates the existence of a receptor, although identity has not been confirmed.

Prostaglandin receptors: PTGER₂, PTGER₄, PTGDR, PTGFR, and PTGER₃IV.

EETs, epoxyeicosatrienoic acids; HETE, hydroxyeicosatetraenoic acids; PPARγ, peroxisome proliferator-activated receptor γ; PTGIR, prostacyclin receptor; TP, thromboxane-prostanoid receptor.