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. 2018 Mar 13;13(3):e0193334. doi: 10.1371/journal.pone.0193334

Table 3. Selected functional genetic ontology (GO) pathways identified in asthmatic airway epithelial differentiated cells after mechanical injury in 8 hours.

Go term
Name
P value Adjusted P-value In query set In whole genome Genes
GO:0034097
response to cytokine
1.9E-20 1.0E-16 59 825 ETS1,KLF4,KLF2,ZBP1,CCL5,FLRT3,FLRT2,HSPA5,VLDLR,ZC3H12A,KLF6,WNT5A,ICAM1,IFITM1,BIRC3,IFIT2,IFIT1,IFIT3,RSAD2,CSF3,ISG15,OASL,XAF1,SNCA,IL1RN,IFI6,IL6,MX1,IL7R,MX2,SPARC,TNFSF14,IRAK2,GBP1,IRF7,ISG20,PTGER4,PTGS2,STAT1,STAT5A,GHR,JUN,GBP4,NFKB2,NFKBIA,KYNU,TRIM31,OAS1,OAS2,OAS3,CXCL2,EDN1,OXTR,SERPINE1,CD44,TNF,IL1RL1,TNFAIP3,IL36G
GO:0006952
defense response
1.6E-19 4.5E-16 84 1651 TNIP3,ETS1,TNIP1,CD83,KLF4,ADAM8,F2R,S100A7,ZBP1,SAA1,ADRB2,HIST1H3D,SCD,CCL5,PMAIP1,IL19,DUOXA2,TPST1,DDIT4,ZC3H12A,WNT5A,ICAM1,IFITM1,BIRC3,SP110,IL23A,IFIT2,IFIT1,IFIT3,SLC7A2,RSAD2,ISG15,SH2D1B,OASL,PDE5A,XAF1,SNCA,STX11,IL1RN,MAP2K3,IFI6,IL6,MX1,MX2,HDAC9,ZNF148,TICAM1,IL17C,MTSS1,CD55,IRAK2,GBP1,IRF7,ISG20,BCL3,PTGER4,ZP3,PTGS2,STAT1,STAT5A,IFIH1,GJA1,BNIP3,BNIP3L,GBP4,NFKB2,NFKBIA,KYNU,NR1D2,TRIM31,OAS1,OAS2,OAS3,CXCL2,EDN1,P2RY11,SERPINE1,CD44,TNF,IL1RL1,TNFAIP3,LYN,IL36G,HERC5
GO:0009607
response to biotic stimulus
1.9E-18 2.1E-15 63 1027 TNIP3,F2R,S100A7,ZBP1,HIST1H3D,SCD,CCL5,HSPA5,PMAIP1,VLDLR,DDIT4,ZC3H12A,WNT5A,ICAM1,IFI44,IFITM1,BIRC3,SP110,IL23A,IFIT2,IFIT1,IFIT3,IVNS1ABP,RSAD2,CSF2,CSF3,ISG15,OASL,SNCA,IL6,MX1,MX2,SPARC,TICAM1,MTSS1,CD55,IRAK2,GBP1,IRF7,ISG20,BCL3,PTGER4,PTGS2,STAT1,IFIH1,JUN,BNIP3,BNIP3L,GBP4,NFKB2,NFKBIA,OAS1,OAS2,OAS3,ODC1,CXCL2,EDN1,SERPINE1,TNF,TNFAIP3,LYN,TRIB1,HERC5
GO:0060337
type I interferon signaling pathway
1.6E-16 1.2E-13 19 81 ZBP1,WNT5A,IFITM1,IFIT2,IFIT1,IFIT3,RSAD2,ISG15,OASL,XAF1,IFI6,MX1,MX2,IRF7,ISG20,STAT1,OAS1,OAS2,OAS3
GO:0005125
cytokine activity
3.8E-07 1.2E-04 17 222 CCL5,IL19,GDF15,WNT5A,IL23A,CSF2,CSF3,IL1RN,IL6,TNFSF14,IL17C,CXCL2,EDN1,LIF,TNF,CMTM7,IL36G
GO:0005126
cytokine receptor binding
1.4E-05 3.3E-03 17 289 TGFBRAP1,CCL5,GDF15,IL23A,CSF2,CSF3,IL1RN,IL6,TNFSF14,IL17C,STAT1,CXCL2,LIF,CD44,TNF,LYN,IL36G
GO:0070851
growth factor receptor binding
4.2E-05 8.1E-03 11 143 VAV3,FLRT3,FLRT2,CSF2,CSF3,IL1RN,IL6,HBEGF,CD44,LYN,IL36G