Table 3. Selected functional genetic ontology (GO) pathways identified in asthmatic airway epithelial differentiated cells after mechanical injury in 8 hours.
Go term Name |
P value | Adjusted P-value | In query set | In whole genome | Genes |
---|---|---|---|---|---|
GO:0034097 response to cytokine |
1.9E-20 | 1.0E-16 | 59 | 825 | ETS1,KLF4,KLF2,ZBP1,CCL5,FLRT3,FLRT2,HSPA5,VLDLR,ZC3H12A,KLF6,WNT5A,ICAM1,IFITM1,BIRC3,IFIT2,IFIT1,IFIT3,RSAD2,CSF3,ISG15,OASL,XAF1,SNCA,IL1RN,IFI6,IL6,MX1,IL7R,MX2,SPARC,TNFSF14,IRAK2,GBP1,IRF7,ISG20,PTGER4,PTGS2,STAT1,STAT5A,GHR,JUN,GBP4,NFKB2,NFKBIA,KYNU,TRIM31,OAS1,OAS2,OAS3,CXCL2,EDN1,OXTR,SERPINE1,CD44,TNF,IL1RL1,TNFAIP3,IL36G |
GO:0006952 defense response |
1.6E-19 | 4.5E-16 | 84 | 1651 | TNIP3,ETS1,TNIP1,CD83,KLF4,ADAM8,F2R,S100A7,ZBP1,SAA1,ADRB2,HIST1H3D,SCD,CCL5,PMAIP1,IL19,DUOXA2,TPST1,DDIT4,ZC3H12A,WNT5A,ICAM1,IFITM1,BIRC3,SP110,IL23A,IFIT2,IFIT1,IFIT3,SLC7A2,RSAD2,ISG15,SH2D1B,OASL,PDE5A,XAF1,SNCA,STX11,IL1RN,MAP2K3,IFI6,IL6,MX1,MX2,HDAC9,ZNF148,TICAM1,IL17C,MTSS1,CD55,IRAK2,GBP1,IRF7,ISG20,BCL3,PTGER4,ZP3,PTGS2,STAT1,STAT5A,IFIH1,GJA1,BNIP3,BNIP3L,GBP4,NFKB2,NFKBIA,KYNU,NR1D2,TRIM31,OAS1,OAS2,OAS3,CXCL2,EDN1,P2RY11,SERPINE1,CD44,TNF,IL1RL1,TNFAIP3,LYN,IL36G,HERC5 |
GO:0009607 response to biotic stimulus |
1.9E-18 | 2.1E-15 | 63 | 1027 | TNIP3,F2R,S100A7,ZBP1,HIST1H3D,SCD,CCL5,HSPA5,PMAIP1,VLDLR,DDIT4,ZC3H12A,WNT5A,ICAM1,IFI44,IFITM1,BIRC3,SP110,IL23A,IFIT2,IFIT1,IFIT3,IVNS1ABP,RSAD2,CSF2,CSF3,ISG15,OASL,SNCA,IL6,MX1,MX2,SPARC,TICAM1,MTSS1,CD55,IRAK2,GBP1,IRF7,ISG20,BCL3,PTGER4,PTGS2,STAT1,IFIH1,JUN,BNIP3,BNIP3L,GBP4,NFKB2,NFKBIA,OAS1,OAS2,OAS3,ODC1,CXCL2,EDN1,SERPINE1,TNF,TNFAIP3,LYN,TRIB1,HERC5 |
GO:0060337 type I interferon signaling pathway |
1.6E-16 | 1.2E-13 | 19 | 81 | ZBP1,WNT5A,IFITM1,IFIT2,IFIT1,IFIT3,RSAD2,ISG15,OASL,XAF1,IFI6,MX1,MX2,IRF7,ISG20,STAT1,OAS1,OAS2,OAS3 |
GO:0005125 cytokine activity |
3.8E-07 | 1.2E-04 | 17 | 222 | CCL5,IL19,GDF15,WNT5A,IL23A,CSF2,CSF3,IL1RN,IL6,TNFSF14,IL17C,CXCL2,EDN1,LIF,TNF,CMTM7,IL36G |
GO:0005126 cytokine receptor binding |
1.4E-05 | 3.3E-03 | 17 | 289 | TGFBRAP1,CCL5,GDF15,IL23A,CSF2,CSF3,IL1RN,IL6,TNFSF14,IL17C,STAT1,CXCL2,LIF,CD44,TNF,LYN,IL36G |
GO:0070851 growth factor receptor binding |
4.2E-05 | 8.1E-03 | 11 | 143 | VAV3,FLRT3,FLRT2,CSF2,CSF3,IL1RN,IL6,HBEGF,CD44,LYN,IL36G |