Video 4. Performance after Top 20% CLV.
Representative example of a unilateral SCI rat performing the isometric pull task at the conclusion of six weeks of Top 20% CLV therapy. Note the improvements in motor control and increase in forelimb pull force compared to after SCI. (A) The plot on the bottom left displays pull force applied to the handle on an individual trial. The green line indicates the adaptive-scaled force threshold to trigger delivery of a reward pellet. Note that the threshold adaptively scales based on the median peak force of the ten antecedent trials. The red line denotes the stimulation threshold based on the top 20% of peak pull force from the preceding 10 trials. Vertical red lines indicate VNS delivery when pull force exceeds the stimulation threshold. The triangle indicates peak pull force on a trial. (B) The plot on the bottom right shows performance over the course of the session. Each circle indicates peak force from an individual trial. Green circles indicate trials in which pull force exceeded the reward threshold. Green circles with a red border indicate trials on which VNS was delivered (the top 20% of trials). White circles indicate trials in which peak force did not exceed the reward threshold.