Table 1.

True and estimated weights (averaged over 100 simulation samples) to combine three markers for the maximum ratio of mean and SD (efficacy comparison assumed at the end of trial i.e., time=3, N=sample size for both training and validation data sets ρ=0.2, r=0.2)

N	True weights	Estimated weights	Bias (MSE) on weights	True Mean/SD	Estimated Mean/SD
40	0.4412 0.5079 0.5787	0.4502 0.5246 0.5739	0.0070 0.0136	-1.6804	-1.6476
60	0.4412 0.5079 0.5787	0.4756 0.5206 0.5960	0.0215 0.0106	-1.6804	-1.6973
80	0.4412 0.5079 0.5787	0.4644 0.5266 0.6079	0.0237 0.0084	-1.6804	-1.6514
100	0.4412 0.5079 0.5787	0.4499 0.5228 0.6023	0.0158 0.0057	-1.6804	-1.6964
120	0.4412 0.5079 0.5787	0.4464 0.5145 0.5800	0.0044 0.0045	-1.6804	-1.6802
140	0.4412 0.5079 0.5787	0.4422 0.5286 0.5965	0.0132 0.0036	-1.6804	-1.6711