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. Author manuscript; available in PMC: 2018 Mar 13.
Published in final edited form as: Biostat Epidemiol. 2017 Jun 2;1(1):36–58. doi: 10.1080/24709360.2017.1331821

Table 4.

Total sample sizes required for 80% power to detect specified effect sizes (ES) at Year3 in each individual marker from the DIAN data.

ES MMSE WORDDEL PAPER DIGSYM PAIRBINDING BOSTON
20% 909 1329 1521 1630 20040 22858
25% 582 851 973 1044 12826 14630
30% 404 591 676 725 8907 10160
35% 297 434 497 533 6544 7464
40% 228 333 381 408 5010 5715
45% 180 263 301 322 3959 4516
50% 146 213 244 261 3207 3658