Table 5.
Weights and total sample sizes required for 80% power to detect specified effect sizes (ES) at Year 3 in each combined marker composed of MMSE (individual marker associated with smallest sample sizes) and each remaining individual marker from the DIAN data.
| MMSE | MMSE | MMSE | MMSE | MMSE | |
|---|---|---|---|---|---|
| PAPER | PAIRBINDING | WORDDEL | DIGSYM | BOSTON | |
|
| |||||
| Estimated | 0.7283 | 0.5397 | 0.9507 | 0.7462 | 0.4992 |
| weights | 0.2692 | 0.1218 | 0.4532 | 0.1803 | 0.0763 |
|
| |||||
| ES | |||||
|
| |||||
| 20% | 536 | 576 | 583 | 1133 | 1137 |
|
| |||||
| 25% | 343 | 369 | 373 | 725 | 728 |
|
| |||||
| 30% | 239 | 256 | 259 | 504 | 505 |
|
| |||||
| 35% | 175 | 188 | 191 | 370 | 371 |
|
| |||||
| 40% | 134 | 144 | 146 | 284 | 285 |
|
| |||||
| 45% | 106 | 114 | 116 | 224 | 225 |
|
| |||||
| 50% | 86 | 93 | 94 | 182 | 182 |