Table 6.
Weights and total sample sizes required for 80% power to detect specified effect sizes (ES) at Year 3 in each combined marker composed of MMSE & PAPER (composite of two markers associated with smallest sample sizes) and each remaining individual marker from the DIAN data.
| MMSE | MMSE | MMSE | MMSE | |
|---|---|---|---|---|
| PAPER | PAPER | PAPER | PAPER | |
| WORDDEL | PAIRBINDING | DIGSYM | BOSTON | |
|
| ||||
| Estimated | 2.6552 | 0.6648 | 1.0049 | 0.3315 |
| weights | 0.9815 | 0.2458 | 0.3714 | 0.1225 |
| 2.5862 | 0.2295 | 0.6970 | 0.1739 | |
|
| ||||
| ES | ||||
|
| ||||
| 20% | 218 | 532 | 750 | 764 |
|
| ||||
| 25% | 140 | 340 | 480 | 489 |
|
| ||||
| 30% | 97 | 237 | 334 | 340 |
|
| ||||
| 35% | 72 | 174 | 245 | 250 |
|
| ||||
| 40% | 55 | 133 | 188 | 191 |
|
| ||||
| 45% | 43 | 105 | 149 | 151 |
|
| ||||
| 50% | 35 | 85 | 120 | 123 |