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. Author manuscript; available in PMC: 2018 Mar 13.
Published in final edited form as: Obesity (Silver Spring). 2016 Nov 2;25(1):155–165. doi: 10.1002/oby.21701

Figure 2. OCA reduced liver weight and hepatic lipid partitioning in Wt but not foz/foz mice.

Figure 2

(A) Liver weight, (B) neutral lipids (as oil red-O [ORO] incorporation), (C) triglyceride, (D) total fatty acids, and (E) free cholesterol and cholesteryl esters in atherogenic diet-fed foz/foz mice vs. Wt with or without OCA treatment. (F) Representative liver sections showing atherogenic diet (Ath)-fed Wt mice developed mild steatosis, but foz/foz mice developed NASH and OCA had no beneficial effect (Table 1). Data are mean ± SEM (n=9-10/gp). *P<0.05 vs. genotype-matched control (treatment effect), δP<0.05 vs. treatment-matched control (genotype effect).