. Author manuscript; available in PMC: 2018 Mar 13.

Published in final edited form as: Obesity (Silver Spring). 2016 Nov 2;25(1):155–165. doi: 10.1002/oby.21701

TABLE 1.

Effects of Obeticholic Acid on Liver Histology in foz/foz and Wt Mice Fed an Atherogenic Diet

		n	Steatosis score	Inflammation score	Ballooning score	NAS^#	Designation

Wt	Control	9	0.22 (0-1)	0.22 (0-1)	0.22 (0-1)	0.67 (0-3)	Normal (7), simple steatosis (1), definite NASH (1)
Wt	OCA	9	0.22 (0-1)	0 (0)	0 (0)	0.33 (0-2)	Normal (7), simple steatosis (2)
foz/foz	Control	9	2.56^δ (1-3)	1.56^δ (1-2)	1.89^δ (1-2)	6.00^δ (3-7)	Definite NASH (9)
foz/foz	OCA	9	2.60^δ (2-3)	1.20^δ (0-2)	1.60^δ (1-2)	5.40^δ (4-7)	Simple steatosis (1), definite NASH (8)

Data are mean (range), representing expert pathologist scoring of global liver pathology (31).

^δ

P<0.05 (vs. treatment-matched, genotype comparison).

NAS, NAFLD activity score. Ath, atherogenic.