Table 4.
Immunity among fully vaccinated PHIV children by viral load and CD4% at four year old visit
| Vaccine | Serologic immunity1 | Viral load (VL) at 4-year-old visit | CD4% at 4-year-old visit | ||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| N | <1000 copies/mL N (%) |
≥1000 copies/mL N (%) |
P- value2 | N3 | CD4% ≥25% N (%) |
CD4% <25% N (%) |
P-value2 | ||
|
| |||||||||
| HBV | Yes | 23 | 15 (24.6) | 8 (16.3) | 0.35 | 22 | 19 (25.0) | 3 (13.0) | 0.27 |
| No | 87 | 46 (75.4) | 41 (83.7) | 77 | 57 (75.0) | 20 (87.0) | |||
|
| |||||||||
| Tetanus4 | Yes | 54 | 40 (85.1) | 14 (50.0) | <0.01 | 51 | 41 (74.6) | 10 (76.9) | 1.0 |
| No | 21 | 7 (14.9) | 14 (50.0) | 17 | 14 (25.4) | 3 (23.1) | |||
|
| |||||||||
| Hib | Yes | 56 | 35 (56.4) | 21 (44.7) | 0.25 | 52 | 42 (53.2) | 10 (43.5) | 0.48 |
| No | 53 | 27 (43.6) | 26 (55.3) | 50 | 37 (46.8) | 13 (56.5) | |||
|
| |||||||||
| Measles | Yes | 77 | 47 (81.0) | 30 (79.0) | 0.80 | 72 | 52 (80.0) | 20 (95.2) | 0.17 |
| No | 19 | 11 (19.0) | 8 (21.0) | 14 | 13 (20.0) | 1 (4.8) | |||
|
| |||||||||
| Rubella | Yes | 70 | 45 (77.6) | 25 (65.8) | 0.24 | 62 | 49 (75.4) | 13 (61.9) | 0.27 |
| No | 26 | 13 (22.4) | 13 (34.2) | 24 | 16 (24.6) | 8 (38.1) | |||
1
Immunity defined as: hepatitis B surface antibody titer ≥10 IU/L, tetanus antibody titer ≥0.1 IU/mL, Hib antibody titer ≥1.0 μg/mL, measles antibody titer ≥0.120 IU/mL, rubella antibody titer ≥10 IU/mL. Non-immune category includes equivocal results for tetanus and Hib.
2
P-values obtained using Fisher’s exact test.
3
CD4% obtained from visit prior to serology testing (missing values not shown).