Table 5.
Relationship between timing of cART initiation and serologic immunity among fully vaccinated PHIV children
| Vaccine | Serologic immunity1 | N | cART initiated <12 months of age N (%) |
cART initiated ≥ 12 months of age N (%) |
No cART N (%) |
P-value2 |
|---|---|---|---|---|---|---|
|
| ||||||
| HBV | Immune | 23 | 15 (31.9) | 7 (14.9) | 1 (6.2) | 0.049 |
| Not immune | 87 | 32 (68.1) | 40 (85.1) | 15 (93.8) | ||
|
| ||||||
| Tetanus3 | Immune | 54 | 24 (72.7) | 25 (75.8) | 5 (55.6) | 0.521 |
| Not immune | 21 | 9 (27.3) | 8 (24.2) | 4 (44.4) | ||
|
| ||||||
| Hib | Immune | 56 | 27 (57.4) | 22 (44.9) | 7 (53.8) | 0.489 |
| Not immune | 53 | 20 (42.6) | 27 (55.1) | 6 (46.2) | ||
|
| ||||||
| Measles | Immune | 77 | 33 (86.8) | 33 (76.7) | 11 (73.3) | 0.405 |
| Not immune | 19 | 5 (13.2) | 10 (23.3) | 4 (26.7) | ||
|
| ||||||
| Rubella | Immune | 70 | 32 (84.2) | 29 (67.4) | 9 (60.0) | 0.20 |
| Not immune | 26 | 6 (15.8) | 14 (32.6) | 6 (40.0) | ||
1
Considered immune to disease as follows; hepatitis B titer ≥10 IU/L, tetanus titer ≥ 0.1 IU/mL, Hib titer ≥ 1.0 μg/mL, measles titer ≥ 0.120 IU/mL, rubella titer ≥ 10 IU/mL. Equivocal results considered non-immune for tetanus and Hib.
2
P- values obtained using Fisher’s exact test.
3
Missing one serologic result for tetanus.