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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Exp Neurol. 2018 Jan 4;302:129–135. doi: 10.1016/j.expneurol.2018.01.004

Figure 3.

Figure 3

Accelerated muscle denervation and wasting in GCLM(−/−)/hSOD1WT+ mice. Expression of the acetylcholine receptor gamma subunit (cholinergic receptor nicotinic gamma subunit, Chrng) (A) and acetylcholine receptor alpha1 subunit (cholinergic receptor nicotinic alpha 1 subunit, Chrna1) (B) in the gastrocnemius muscle of 60 weeks old animals from the indicated genotypes. For A and B data are expressed as percentage of GCLM(+/+)/hSOD1WT-animals (mean±SD; n=3–5). * Significantly different from GCLM(+/+)/hSOD1WT− (p<0.05). # Significantly different from GCLM(+/+)/hSOD1WT+ (p<0.05). C) Gastrocnemius muscle weight from 60 weeks old GCLM(+/+)/hSOD1WT+ and GCLM(−/−)/hSOD1WT+ mice (*p<0.05). D) Representative image of the gastrocnemius muscle from 60 weeks old GCLM(+/+)/hSOD1WT+ and GCLM(−/−)/hSOD1WT+ mice. Scale bar: 1 cm. E) Hematoxylin and eosin staining in gastrocnemius muscle sections from GCLM(+/+)/hSOD1WT+ and GCLM(−/−)/hSOD1WT+ mice. Scale bar: 200 μm.