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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Drug Discov Today. 2018 Jan 10;23(3):696–703. doi: 10.1016/j.drudis.2018.01.027

Figure 2.

Figure 2

The experimental scheme summarizing generation of reporter lines of diseased corticospinal motor neurons (CSMNs). (a) Mouse models of amyotrophic lateral sclerosis (ALS) that display CSMN vulnerability and progressive degeneration are crossed with the UCHL1-eGFP mice to generate CSMN reporter lines of ALS mouse models. This simple approach is used to generate hSOD1G93A-UeGFP, TDP43-UeGFP, AlsinKO-UeGFP mice, and the same approach can be used to generate other reporter lines of diseased CSMNs after other mouse models are generated and the timing and extent of their CSMN loss is well reported.