Table 1.
Clinical Characteristics of FHS and MDCS Participants.
| FHS GWAS |
FHS Exome Array |
MDCS Nested Case-Control |
MDCS Case- Cohort |
|
|---|---|---|---|---|
|
|
||||
| Number of Individuals | 759 | 746 | 554 | 867 |
|
|
||||
| Age (years) | 56.1 (±9.8) | 55.6 (±9.7) | 59.0 (±5.7) | 58.2 (±6.0) |
|
|
||||
| Female (N,%) | 399 (49.6%) | 397 (49.3%) | 298 (53.8%) | 529 (52.4%) |
|
|
||||
| BMI | 27.6 (±4.9) | 27.6 (±5.0) | 27.2 (±4.6) | 26.0 (±4.1) |
|
|
||||
| Total Cholesterol (mg/dL) | 208 (±38) | 208 (±37) | 243 (±42) | 238 (±41) |
|
|
||||
| Triglycerides (mg/dL) | 155 (±109) | 155 (±112) | 134 (±63) | 124 (±69) |
|
|
||||
| HDL Cholesterol (mg/dL) | 49 (±15) | 49 (±15) | 50 (±12) | 53 (±14) |
|
|
||||
| LDL Cholesterol (mg/dL) | 129 (±34) | 129 (±32) | 167 (±38) | 161 (±38) |
|
|
||||
| Diabetes (N, %) | 60 (7.5%) | 52 (6.5%) | 23 (4.2%) | 61 (6.0%) |
|
|
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| Treatment for Hypertension (N, %) | 286 (35.5%) | 276 (34.3%) | 132 (23.8%) | 214 (21.2%) |
|
|
||||
| Systolic Blood Pressure (mmHg) | 128 (±20) | 128 (±19) | 147 (±18) | 142 (± 19) |
|
|
||||
| Smoker (N, %) | 144 (17.9%) | 143 (17.8%) | 180 (32.5%) | 285 (29.2%) |
|
|
||||
Characteristics of the participants in the FHS discovery and MDCS validation cohorts who underwent proteomic and genomic profiling. Data represent means (standard deviation) unless otherwise noted.